FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1939591165> ?p ?o ?g. }

• W1939591165 endingPage "26" @default.
• W1939591165 startingPage "20" @default.
• W1939591165 abstract "Following stroke or traumatic damage, neuronal death via both necrosis and apoptosis causes loss of functions, including memory, sensory perception, and motor skills. As necrosis has the nature to expand, while apoptosis stops the cell death cascade in the brain, necrosis is considered to be a promising target for rapid treatment for stroke. We identified the nuclear protein, prothymosin alpha (ProTα) from the conditioned medium of serum‐free culture of cortical neurons as a key protein‐inhibiting necrosis. In the culture of cortical neurons in the serum‐free condition without any supplements, ProTα inhibited the necrosis, but caused apoptosis. In the ischemic brain or retina, ProTα showed a potent inhibition of both necrosis and apoptosis. By use of anti‐brain‐derived neurotrophic factor or anti‐erythropoietin IgG, we found that ProTα inhibits necrosis, but causes apoptosis, which is in turn inhibited by ProTα‐induced neurotrophins under the condition of ischemia. From the experiment using anti‐ProTα IgG or antisense oligonucleotide for ProTα, it was revealed that ProTα has a pathophysiological role in protecting neurons in stroke." @default.
• W1939591165 created "2016-06-24" @default.
• W1939591165 creator A5004599981 @default.
• W1939591165 creator A5016008286 @default.
• W1939591165 creator A5050196544 @default.
• W1939591165 creator A5060473938 @default.
• W1939591165 date "2010-05-01" @default.
• W1939591165 modified "2023-09-27" @default.
• W1939591165 title "Prothymosin α as robustness molecule against ischemic stress to brain and retina" @default.
• W1939591165 cites W140025526 @default.
• W1939591165 cites W1498166809 @default.
• W1939591165 cites W1514513302 @default.
• W1939591165 cites W1964780858 @default.
• W1939591165 cites W1973150007 @default.
• W1939591165 cites W1973265746 @default.
• W1939591165 cites W1982313065 @default.
• W1939591165 cites W1998555534 @default.
• W1939591165 cites W2010154644 @default.
• W1939591165 cites W2017281018 @default.
• W1939591165 cites W2028590636 @default.
• W1939591165 cites W2048740980 @default.
• W1939591165 cites W2051148579 @default.
• W1939591165 cites W2051301115 @default.
• W1939591165 cites W2062930328 @default.
• W1939591165 cites W2062993799 @default.
• W1939591165 cites W2078738990 @default.
• W1939591165 cites W2085517668 @default.
• W1939591165 cites W2086263831 @default.
• W1939591165 cites W2096043228 @default.
• W1939591165 cites W2106917466 @default.
• W1939591165 cites W2125947566 @default.
• W1939591165 cites W2140556022 @default.
• W1939591165 cites W2142003764 @default.
• W1939591165 doi "https://doi.org/10.1111/j.1749-6632.2010.05466.x" @default.
• W1939591165 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20536446" @default.
• W1939591165 hasPublicationYear "2010" @default.
• W1939591165 type Work @default.
• W1939591165 sameAs 1939591165 @default.
• W1939591165 citedByCount "15" @default.
• W1939591165 countsByYear W19395911652012 @default.
• W1939591165 countsByYear W19395911652013 @default.
• W1939591165 countsByYear W19395911652015 @default.
• W1939591165 countsByYear W19395911652016 @default.
• W1939591165 countsByYear W19395911652017 @default.
• W1939591165 countsByYear W19395911652018 @default.
• W1939591165 countsByYear W19395911652019 @default.
• W1939591165 countsByYear W19395911652020 @default.
• W1939591165 crossrefType "journal-article" @default.
• W1939591165 hasAuthorship W1939591165A5004599981 @default.
• W1939591165 hasAuthorship W1939591165A5016008286 @default.
• W1939591165 hasAuthorship W1939591165A5050196544 @default.
• W1939591165 hasAuthorship W1939591165A5060473938 @default.
• W1939591165 hasConcept C126322002 @default.
• W1939591165 hasConcept C142724271 @default.
• W1939591165 hasConcept C169760540 @default.
• W1939591165 hasConcept C17991360 @default.
• W1939591165 hasConcept C190283241 @default.
• W1939591165 hasConcept C203014093 @default.
• W1939591165 hasConcept C2777093970 @default.
• W1939591165 hasConcept C31573885 @default.
• W1939591165 hasConcept C503630168 @default.
• W1939591165 hasConcept C541997718 @default.
• W1939591165 hasConcept C55493867 @default.
• W1939591165 hasConcept C71924100 @default.
• W1939591165 hasConcept C86803240 @default.
• W1939591165 hasConcept C95444343 @default.
• W1939591165 hasConceptScore W1939591165C126322002 @default.
• W1939591165 hasConceptScore W1939591165C142724271 @default.
• W1939591165 hasConceptScore W1939591165C169760540 @default.
• W1939591165 hasConceptScore W1939591165C17991360 @default.
• W1939591165 hasConceptScore W1939591165C190283241 @default.
• W1939591165 hasConceptScore W1939591165C203014093 @default.
• W1939591165 hasConceptScore W1939591165C2777093970 @default.
• W1939591165 hasConceptScore W1939591165C31573885 @default.
• W1939591165 hasConceptScore W1939591165C503630168 @default.
• W1939591165 hasConceptScore W1939591165C541997718 @default.
• W1939591165 hasConceptScore W1939591165C55493867 @default.
• W1939591165 hasConceptScore W1939591165C71924100 @default.
• W1939591165 hasConceptScore W1939591165C86803240 @default.
• W1939591165 hasConceptScore W1939591165C95444343 @default.
• W1939591165 hasIssue "1" @default.
• W1939591165 hasLocation W19395911651 @default.
• W1939591165 hasLocation W19395911652 @default.
• W1939591165 hasOpenAccess W1939591165 @default.
• W1939591165 hasPrimaryLocation W19395911651 @default.
• W1939591165 hasRelatedWork W1561393128 @default.
• W1939591165 hasRelatedWork W2005856601 @default.
• W1939591165 hasRelatedWork W2007861801 @default.
• W1939591165 hasRelatedWork W2015705067 @default.
• W1939591165 hasRelatedWork W2044166463 @default.
• W1939591165 hasRelatedWork W2046804643 @default.
• W1939591165 hasRelatedWork W2116199074 @default.
• W1939591165 hasRelatedWork W2291591285 @default.
• W1939591165 hasRelatedWork W2298162161 @default.
• W1939591165 hasRelatedWork W2373118002 @default.
• W1939591165 hasVolume "1194" @default.
• W1939591165 isParatext "false" @default.
• W1939591165 isRetracted "false" @default.

• next