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- W1939707029 abstract "To produce euploid progeny with equal chromosome complements and identical genomes, cells must achieve accurate chromosome segregation during mitosis. Many cellular processes contribute to this fidelity of genome transmission, including the fundamental principle that the identical sister chromatids, produced via DNA replication, must remain physically connected until just before their segregation in anaphase. There are 2 overarching mechanisms that account for the cohesion that is maintained between the sisters.1 Firstly, the nascent DNA molecules emerge from the replicative machinery as physically entwined, or catenated, entities. These cannot be resolved from each other without coupled DNA breakage and re-ligation, known as strand passage reactions, that are completed by Type II topoisomerases in preparation for chromatid segregation. The second cohesive mechanism is broadly defined as protein-mediated cohesion, and involves the activity of numerous proteins, including a protein complex named Cohesin whose ability to tether sister DNA molecules has been the subject of intense study. In this issue of Cell Cycle, Zhang and Pati2 describe a key role for the C-terminus of Sororin, a Cohesin regulatory sub-unit required for maintenance of cohesion in human cells.3,4 This discovery promises to stimulate a new understanding of how Cohesin is regulated by Sororin." @default.
- W1939707029 created "2016-06-24" @default.
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- W1939707029 date "2015-04-18" @default.
- W1939707029 modified "2023-10-15" @default.
- W1939707029 title "Sororin is tethered to Cohesin SA2" @default.
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- W1939707029 doi "https://doi.org/10.1080/15384101.2015.1018055" @default.
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