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- W1939736057 abstract "Sulphydryl compounds have been shown to reduce radiation-induced injury. Chemical modification of the radiation response has received renewed interest as a possible adjunct to radiation in the treatment of cancer [l]. To prevent radiation injury to normal tissue, many radioprotective agents have been developed and some of them have been used clinically [2-81. The maximum tolerated dose and the side effects observed are a limitation for clinical utilization of these drugs. The most widely studied of this group of agents are the thiophosphoroate derivatives of cysteamine (e.g. WR-2721) which act through their free sulphydryl aminothiol part which is liberated in vivo [9-151. New aminothiols associating cysteamine with an amino acid have been recently synthesized by Imbach and co-workers [16]. The latest ones, known under the code-numbes I-143 (HS-(CH,),-CO-NH-(CH,),-SH) and I-145 (CF,COOH, NH,-CH,-CO-NH-(CH,),-SH), were supplied to us by Professor J.L. Imbach (Montpellier University, France) [17]. It should also be noted that I-145 is the free sulphydryl part of the molecule I-102 (I-102 is the S-acetylated form of I-145). The aim of this study was to investigate the electrochemical behaviour of I-143 and I-145 and the interaction of these drugs with DNA and lipids. These experiments are very interesting because when the drug penetrates the cell nucleus it appears that the interaction between the acting molecule and DNA as a target is an important factor of protection. Nevertheless, and important metabolic fraction of I-145 is cysteamine this indicates that this molecule is involved as a “ prodrug”." @default.
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- W1939736057 date "1989-02-01" @default.
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- W1939736057 title "Spectrophotometric and dielectric studies of two new aminothiols" @default.
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- W1939736057 doi "https://doi.org/10.1016/0022-0728(89)87196-7" @default.
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