FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1939850717> ?p ?o ?g. }

• W1939850717 endingPage "6" @default.
• W1939850717 startingPage "4010" @default.
• W1939850717 abstract "Glioblastoma multiforme is the most treatment-resistant brain tumor. Elongation factor-2 (EF-2) kinase (calmodulin kinase III) is a unique protein kinase that is overexpressed in glioma cell lines and in human surgical specimens. Several mitogens activate this kinase and inhibitors block mitogen activation and produce cell death. Geldanamycin (GA) is a benzoquinone ansamycin antibiotic that disrupts Hsp90-protein interactions. Because EF-2 kinase is chaperoned by Hsp90, we investigated the effects of GA on the viability of glioma cells, the expression of EF-2 kinase protein, and the interaction between Hsp90 and EF-2 kinase. GA was a potent inhibitor of the clonogenicity of four glioma cells lines with IC(50)s ranging from 1 to 3 nM. 17-allylamino-17-demethoxygeldanamycin (17-AAG), a less toxic and less potent derivative of GA, inhibited the clonogenicity of glioma cells with IC(50) values of 13 nM in C6 cells and 35 nM in T98G cells. Treatment of cell lines for 24-48 h of GA or 17-AAG disrupted EF-2-kinase/Hsp90 interactions as measured by coimmunoprecipitation, resulting in a decreased amount of recoverable kinase in cell lysates. The ability of GA to inhibit the growth of glioma cells was abrogated by overexpressing EF-2 kinase. In addition, 17-AAG significantly inhibited the growth of a glioma xenograft in nude mice. These studies demonstrate for the first time the activity of GAs against human gliomas in vitro and in vivo and suggest that destruction of EF-2 kinase may be an important cytotoxic mechanism of this unique class of drug." @default.
• W1939850717 created "2016-06-24" @default.
• W1939850717 creator A5002345312 @default.
• W1939850717 creator A5005424988 @default.
• W1939850717 creator A5012792790 @default.
• W1939850717 creator A5068919066 @default.
• W1939850717 creator A5078674610 @default.
• W1939850717 creator A5089449477 @default.
• W1939850717 date "2001-05-15" @default.
• W1939850717 modified "2023-10-17" @default.
• W1939850717 title "Disruption of the EF-2 kinase/Hsp90 protein complex: a possible mechanism to inhibit glioblastoma by geldanamycin." @default.
• W1939850717 cites W1495233477 @default.
• W1939850717 cites W1525412860 @default.
• W1939850717 cites W1538376298 @default.
• W1939850717 cites W1562839697 @default.
• W1939850717 cites W1583656960 @default.
• W1939850717 cites W1586440254 @default.
• W1939850717 cites W1885135345 @default.
• W1939850717 cites W1968966545 @default.
• W1939850717 cites W1971405891 @default.
• W1939850717 cites W1973071934 @default.
• W1939850717 cites W1977392502 @default.
• W1939850717 cites W1977878414 @default.
• W1939850717 cites W1978723696 @default.
• W1939850717 cites W1981012489 @default.
• W1939850717 cites W1986242330 @default.
• W1939850717 cites W1992170822 @default.
• W1939850717 cites W1998900845 @default.
• W1939850717 cites W1999938778 @default.
• W1939850717 cites W2002079983 @default.
• W1939850717 cites W2008245136 @default.
• W1939850717 cites W2036560693 @default.
• W1939850717 cites W2042699875 @default.
• W1939850717 cites W2049546697 @default.
• W1939850717 cites W2052997882 @default.
• W1939850717 cites W2053503219 @default.
• W1939850717 cites W2054712075 @default.
• W1939850717 cites W2061063334 @default.
• W1939850717 cites W2065076407 @default.
• W1939850717 cites W2069412625 @default.
• W1939850717 cites W2074061232 @default.
• W1939850717 cites W2077322645 @default.
• W1939850717 cites W2083890417 @default.
• W1939850717 cites W2086217181 @default.
• W1939850717 cites W2090122242 @default.
• W1939850717 cites W2113012900 @default.
• W1939850717 cites W2130196766 @default.
• W1939850717 cites W2133420284 @default.
• W1939850717 cites W2134913638 @default.
• W1939850717 cites W2150955765 @default.
• W1939850717 cites W2154368304 @default.
• W1939850717 cites W2160587377 @default.
• W1939850717 cites W2162107265 @default.
• W1939850717 cites W2171455978 @default.
• W1939850717 cites W2178587353 @default.
• W1939850717 cites W2286667012 @default.
• W1939850717 cites W2314514496 @default.
• W1939850717 cites W2340946024 @default.
• W1939850717 cites W2402473734 @default.
• W1939850717 cites W2403133344 @default.
• W1939850717 cites W2406432714 @default.
• W1939850717 cites W41186048 @default.
• W1939850717 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11358819" @default.
• W1939850717 hasPublicationYear "2001" @default.
• W1939850717 type Work @default.
• W1939850717 sameAs 1939850717 @default.
• W1939850717 citedByCount "18" @default.
• W1939850717 countsByYear W19398507172014 @default.
• W1939850717 countsByYear W19398507172015 @default.
• W1939850717 countsByYear W19398507172020 @default.
• W1939850717 countsByYear W19398507172021 @default.
• W1939850717 crossrefType "journal-article" @default.
• W1939850717 hasAuthorship W1939850717A5002345312 @default.
• W1939850717 hasAuthorship W1939850717A5005424988 @default.
• W1939850717 hasAuthorship W1939850717A5012792790 @default.
• W1939850717 hasAuthorship W1939850717A5068919066 @default.
• W1939850717 hasAuthorship W1939850717A5078674610 @default.
• W1939850717 hasAuthorship W1939850717A5089449477 @default.
• W1939850717 hasConcept C104317684 @default.
• W1939850717 hasConcept C153911025 @default.
• W1939850717 hasConcept C184235292 @default.
• W1939850717 hasConcept C185592680 @default.
• W1939850717 hasConcept C199649820 @default.
• W1939850717 hasConcept C205260736 @default.
• W1939850717 hasConcept C2775932338 @default.
• W1939850717 hasConcept C2778227246 @default.
• W1939850717 hasConcept C2780297055 @default.
• W1939850717 hasConcept C502942594 @default.
• W1939850717 hasConcept C55493867 @default.
• W1939850717 hasConcept C82495950 @default.
• W1939850717 hasConcept C86803240 @default.
• W1939850717 hasConcept C95444343 @default.
• W1939850717 hasConcept C97029542 @default.
• W1939850717 hasConceptScore W1939850717C104317684 @default.
• W1939850717 hasConceptScore W1939850717C153911025 @default.
• W1939850717 hasConceptScore W1939850717C184235292 @default.
• W1939850717 hasConceptScore W1939850717C185592680 @default.
• W1939850717 hasConceptScore W1939850717C199649820 @default.

• next