Matches in SemOpenAlex for { <https://semopenalex.org/work/W1939947110> ?p ?o ?g. }
Showing items 1 to 83 of
83
with 100 items per page.
- W1939947110 endingPage "30" @default.
- W1939947110 startingPage "222" @default.
- W1939947110 abstract "Maitotoxin (MTX) increases formation of [3H]inositol phosphates from phosphoinositides and release of [3H]arachidonic acid from phospholipids in pheochromocytoma PC12 cells. Formation of [3H]inositol phosphates is detected within 1 min of incubation even with concentrations as low as 0.3 ng/ml (90 pm) MTX, whereas release of [3H]arachidonic acid is not detected until 20 min even with concentrations as high as 1 ng/ml (300 pm) MTX. Stimulation of arachidonic acid release can be detected at 0.03 ng/ml (9 pm) MTX, whereas 0.1 ng/ml (30 pm) MTX is the threshold for detection of phosphoinositide breakdown. Organic and inorganic calcium channel blockers, except Cd2+ and a high concentration of Mn2+, have no effect on MTX-elicited phosphoinositide breakdown, whereas inorganic blockers (e.g., Co2+, Mn2+, Cd2+), but not organic blockers (nifedipine, verapamil, diltiazem), inhibit MTX-stimulated arachidonic acid release. All calcium channel blockers, however, inhibited MTX-elicited influx of 45Ca2+ and the MTX-elicited increase in internal Ca2+ measured with fura-2 was markedly reduced by nifedipine. MTX-elicited phosphoinositide breakdown and arachidonic acid release are abolished or reduced, respectively, in the absence of extracellular calcium plus chelating agent. The calcium ionophore A23187 has little or no effect alone but, in combination with MTX, A23187 inhibits MTX-elicited phosphoinositide breakdown and enhances arachidonic acid release, the latter even in the absence of extracellular calcium. The results suggest that different sites and/or mechanisms are involved in stimulation of calcium influx, breakdown of phosphoinositides, and release of arachidonic acid by MTX." @default.
- W1939947110 created "2016-06-24" @default.
- W1939947110 creator A5022742067 @default.
- W1939947110 creator A5032484241 @default.
- W1939947110 creator A5033483377 @default.
- W1939947110 creator A5034131737 @default.
- W1939947110 creator A5040410945 @default.
- W1939947110 creator A5070411773 @default.
- W1939947110 date "1990-02-01" @default.
- W1939947110 modified "2023-10-16" @default.
- W1939947110 title "Maitotoxin: effects on calcium channels, phosphoinositide breakdown, and arachidonate release in pheochromocytoma PC12 cells." @default.
- W1939947110 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2154671" @default.
- W1939947110 hasPublicationYear "1990" @default.
- W1939947110 type Work @default.
- W1939947110 sameAs 1939947110 @default.
- W1939947110 citedByCount "9" @default.
- W1939947110 countsByYear W19399471102017 @default.
- W1939947110 crossrefType "journal-article" @default.
- W1939947110 hasAuthorship W1939947110A5022742067 @default.
- W1939947110 hasAuthorship W1939947110A5032484241 @default.
- W1939947110 hasAuthorship W1939947110A5033483377 @default.
- W1939947110 hasAuthorship W1939947110A5034131737 @default.
- W1939947110 hasAuthorship W1939947110A5040410945 @default.
- W1939947110 hasAuthorship W1939947110A5070411773 @default.
- W1939947110 hasConcept C134018914 @default.
- W1939947110 hasConcept C153461711 @default.
- W1939947110 hasConcept C170493617 @default.
- W1939947110 hasConcept C178790620 @default.
- W1939947110 hasConcept C181199279 @default.
- W1939947110 hasConcept C185592680 @default.
- W1939947110 hasConcept C18699975 @default.
- W1939947110 hasConcept C24998067 @default.
- W1939947110 hasConcept C2776741139 @default.
- W1939947110 hasConcept C2777022698 @default.
- W1939947110 hasConcept C2777427919 @default.
- W1939947110 hasConcept C2778078955 @default.
- W1939947110 hasConcept C2779066535 @default.
- W1939947110 hasConcept C28406088 @default.
- W1939947110 hasConcept C519063684 @default.
- W1939947110 hasConcept C55493867 @default.
- W1939947110 hasConcept C85520022 @default.
- W1939947110 hasConcept C86803240 @default.
- W1939947110 hasConcept C98274493 @default.
- W1939947110 hasConceptScore W1939947110C134018914 @default.
- W1939947110 hasConceptScore W1939947110C153461711 @default.
- W1939947110 hasConceptScore W1939947110C170493617 @default.
- W1939947110 hasConceptScore W1939947110C178790620 @default.
- W1939947110 hasConceptScore W1939947110C181199279 @default.
- W1939947110 hasConceptScore W1939947110C185592680 @default.
- W1939947110 hasConceptScore W1939947110C18699975 @default.
- W1939947110 hasConceptScore W1939947110C24998067 @default.
- W1939947110 hasConceptScore W1939947110C2776741139 @default.
- W1939947110 hasConceptScore W1939947110C2777022698 @default.
- W1939947110 hasConceptScore W1939947110C2777427919 @default.
- W1939947110 hasConceptScore W1939947110C2778078955 @default.
- W1939947110 hasConceptScore W1939947110C2779066535 @default.
- W1939947110 hasConceptScore W1939947110C28406088 @default.
- W1939947110 hasConceptScore W1939947110C519063684 @default.
- W1939947110 hasConceptScore W1939947110C55493867 @default.
- W1939947110 hasConceptScore W1939947110C85520022 @default.
- W1939947110 hasConceptScore W1939947110C86803240 @default.
- W1939947110 hasConceptScore W1939947110C98274493 @default.
- W1939947110 hasIssue "2" @default.
- W1939947110 hasLocation W19399471101 @default.
- W1939947110 hasOpenAccess W1939947110 @default.
- W1939947110 hasPrimaryLocation W19399471101 @default.
- W1939947110 hasRelatedWork W1939947110 @default.
- W1939947110 hasRelatedWork W1971928146 @default.
- W1939947110 hasRelatedWork W1988074297 @default.
- W1939947110 hasRelatedWork W2016271841 @default.
- W1939947110 hasRelatedWork W2034698869 @default.
- W1939947110 hasRelatedWork W2039661997 @default.
- W1939947110 hasRelatedWork W2148282970 @default.
- W1939947110 hasRelatedWork W2168953710 @default.
- W1939947110 hasRelatedWork W2257026079 @default.
- W1939947110 hasRelatedWork W2001641233 @default.
- W1939947110 hasVolume "37" @default.
- W1939947110 isParatext "false" @default.
- W1939947110 isRetracted "false" @default.
- W1939947110 magId "1939947110" @default.
- W1939947110 workType "article" @default.