Matches in SemOpenAlex for { <https://semopenalex.org/work/W1940256978> ?p ?o ?g. }
Showing items 1 to 94 of
94
with 100 items per page.
- W1940256978 endingPage "5708" @default.
- W1940256978 startingPage "5704" @default.
- W1940256978 abstract "New germ line proviral insertions are acquired at a high frequency by the progeny of SWR/J-RF/J hybrid female mice that carry the endogenous ecotropic murine leukemia proviruses Emv-16 and Emv-17. The tight linkage of these RF/J strain proviral loci has prevented genetic segregation of the retroviral genomes. Hence, it is not known whether both of these proviruses are capable of giving rise to new proviral insertions. We have molecularly cloned Emv-16 and Emv-17 and have characterized them in vitro and in vivo. Restriction enzyme analysis of the recombinant clones revealed that the proviral genomes are very similar to each other and closely resemble the wild-type AKR virus. A comparison of the flanking cellular DNA suggests that the Emv-16 and Emv-17 loci did not arise by simple duplication of a viral insertion site within the RF/J genome but most likely are independent integration events. Both proviruses produce infectious virus when transfected into NIH 3T3 cells, indicating that they are nondefective retroviruses. Exogenous infection of SWR/J mice with either Emv-16 or Emv-17 leads to viremia in the host animals, and in both cases, progeny of viremic females acquire new proviral insertions. The ability of these retroviruses to generate novel retroviral integration sites in the mouse genome provides a simple method for inducing insertional mutations in mice." @default.
- W1940256978 created "2016-06-24" @default.
- W1940256978 creator A5013510074 @default.
- W1940256978 creator A5028634265 @default.
- W1940256978 creator A5083414833 @default.
- W1940256978 date "1993-09-01" @default.
- W1940256978 modified "2023-10-16" @default.
- W1940256978 title "The endogenous ecotropic murine retroviruses Emv-16 and Emv-17 are both capable of producing new proviral insertions in the mouse genome" @default.
- W1940256978 cites W1487072484 @default.
- W1940256978 cites W1489962216 @default.
- W1940256978 cites W1526703861 @default.
- W1940256978 cites W1542702295 @default.
- W1940256978 cites W1657789828 @default.
- W1940256978 cites W1773795528 @default.
- W1940256978 cites W1902662359 @default.
- W1940256978 cites W1916039573 @default.
- W1940256978 cites W1918543915 @default.
- W1940256978 cites W1964407939 @default.
- W1940256978 cites W1978119836 @default.
- W1940256978 cites W1992356597 @default.
- W1940256978 cites W1998162329 @default.
- W1940256978 cites W2003889212 @default.
- W1940256978 cites W2008702912 @default.
- W1940256978 cites W2014015430 @default.
- W1940256978 cites W2050275491 @default.
- W1940256978 cites W2054984155 @default.
- W1940256978 cites W2061375987 @default.
- W1940256978 cites W2078279350 @default.
- W1940256978 cites W2086811876 @default.
- W1940256978 cites W2103441096 @default.
- W1940256978 cites W2116489938 @default.
- W1940256978 cites W2136029008 @default.
- W1940256978 doi "https://doi.org/10.1128/jvi.67.9.5704-5708.1993" @default.
- W1940256978 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/237980" @default.
- W1940256978 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8394469" @default.
- W1940256978 hasPublicationYear "1993" @default.
- W1940256978 type Work @default.
- W1940256978 sameAs 1940256978 @default.
- W1940256978 citedByCount "4" @default.
- W1940256978 crossrefType "journal-article" @default.
- W1940256978 hasAuthorship W1940256978A5013510074 @default.
- W1940256978 hasAuthorship W1940256978A5028634265 @default.
- W1940256978 hasAuthorship W1940256978A5083414833 @default.
- W1940256978 hasBestOaLocation W19402569781 @default.
- W1940256978 hasConcept C104317684 @default.
- W1940256978 hasConcept C121346293 @default.
- W1940256978 hasConcept C141231307 @default.
- W1940256978 hasConcept C153911025 @default.
- W1940256978 hasConcept C159047783 @default.
- W1940256978 hasConcept C199491388 @default.
- W1940256978 hasConcept C2522874641 @default.
- W1940256978 hasConcept C2776185481 @default.
- W1940256978 hasConcept C2779562191 @default.
- W1940256978 hasConcept C40767141 @default.
- W1940256978 hasConcept C54355233 @default.
- W1940256978 hasConcept C552990157 @default.
- W1940256978 hasConcept C86803240 @default.
- W1940256978 hasConceptScore W1940256978C104317684 @default.
- W1940256978 hasConceptScore W1940256978C121346293 @default.
- W1940256978 hasConceptScore W1940256978C141231307 @default.
- W1940256978 hasConceptScore W1940256978C153911025 @default.
- W1940256978 hasConceptScore W1940256978C159047783 @default.
- W1940256978 hasConceptScore W1940256978C199491388 @default.
- W1940256978 hasConceptScore W1940256978C2522874641 @default.
- W1940256978 hasConceptScore W1940256978C2776185481 @default.
- W1940256978 hasConceptScore W1940256978C2779562191 @default.
- W1940256978 hasConceptScore W1940256978C40767141 @default.
- W1940256978 hasConceptScore W1940256978C54355233 @default.
- W1940256978 hasConceptScore W1940256978C552990157 @default.
- W1940256978 hasConceptScore W1940256978C86803240 @default.
- W1940256978 hasIssue "9" @default.
- W1940256978 hasLocation W19402569781 @default.
- W1940256978 hasLocation W19402569782 @default.
- W1940256978 hasLocation W19402569783 @default.
- W1940256978 hasLocation W19402569784 @default.
- W1940256978 hasOpenAccess W1940256978 @default.
- W1940256978 hasPrimaryLocation W19402569781 @default.
- W1940256978 hasRelatedWork W1605241955 @default.
- W1940256978 hasRelatedWork W1940256978 @default.
- W1940256978 hasRelatedWork W1970057644 @default.
- W1940256978 hasRelatedWork W2020740498 @default.
- W1940256978 hasRelatedWork W2075870928 @default.
- W1940256978 hasRelatedWork W2155645215 @default.
- W1940256978 hasRelatedWork W2266664725 @default.
- W1940256978 hasRelatedWork W2403414290 @default.
- W1940256978 hasRelatedWork W3049066810 @default.
- W1940256978 hasRelatedWork W2481551380 @default.
- W1940256978 hasVolume "67" @default.
- W1940256978 isParatext "false" @default.
- W1940256978 isRetracted "false" @default.
- W1940256978 magId "1940256978" @default.
- W1940256978 workType "article" @default.