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- W1940384762 abstract "Primary immune deficiencies, once the sole domain of paediatricians, have come of age, and increasing numbers of childhood survivors, testament to meticulous medical care and the introduction of broad-spectrum antimicrobial prophylaxis, are now reaching early-to-mid adulthood. These patient cohorts are important for a number of reasons: 1) they teach us about the natural history of disease, modified through therapeutic intervention; 2) they highlight patients presenting at the extremes of the spectrum, e.g. with less severe disease, modified by genetics and/or environment; 3) they may offer insights into risks and benefits of earlier intervention in the disease course; and 4) they present a challenge to adult physicians, potentially unfamiliar with hitherto “paediatric” disease and its management.Childhood survivors of chronic granulomatous disease show the importance of expertise in primary immunodeficiencies" @default.
- W1940384762 created "2016-06-24" @default.
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- W1940384762 date "2015-05-31" @default.
- W1940384762 modified "2023-09-23" @default.
- W1940384762 title "Primary immunodeficiencies: not just paediatric diseases" @default.
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- W1940384762 doi "https://doi.org/10.1183/09031936.00020215" @default.
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