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- W1940430771 abstract "The maturation of vertebrate oocyte into haploid gamete, the egg, consists of two specialized asymmetric cell divisions with no intervening S-phase. Ran GTPase has an essential role in relaying the active role of chromosomes in their own segregation by the meiotic process. In addition to its conserved role as a key regulator of macromolecular transport between nucleus and cytoplasm, Ran has important functions during cell division, including in mitotic spindle assembly and in the assembly of nuclear envelope at the exit from mitosis. The cellular functions of Ran are mediated by RanGTP interactions with nuclear transport receptors (NTRs) related to importin β and depend on the existence of chromosome-centered RanGTP gradient. Live imaging with FRET biosensors indeed revealed the existence of RanGTP gradient throughout mouse oocyte maturation. NTR-dependent transport of cell cycle regulators including cyclin B1, Wee2, and Cdc25B between the oocyte cytoplasm and germinal vesicle (GV) is required for normal resumption of meiosis. After GVBD in mouse oocytes, RanGTP gradient is required for timely meiosis I (MI) spindle assembly and provides long-range signal directing egg cortex differentiation. However, RanGTP gradient is not required for MI spindle migration and may be dispensable for MI spindle function in chromosome segregation. In contrast, MII spindle assembly and function in maturing mouse and Xenopus laevis eggs depend on RanGTP gradient, similar to X. laevis MII-derived egg extracts." @default.
- W1940430771 created "2016-06-24" @default.
- W1940430771 creator A5052600113 @default.
- W1940430771 creator A5060353683 @default.
- W1940430771 creator A5076054999 @default.
- W1940430771 date "2011-01-01" @default.
- W1940430771 modified "2023-10-16" @default.
- W1940430771 title "The Role of RanGTP Gradient in Vertebrate Oocyte Maturation" @default.
- W1940430771 cites W1529934215 @default.
- W1940430771 cites W1532291942 @default.
- W1940430771 cites W1563529848 @default.
- W1940430771 cites W1565506774 @default.
- W1940430771 cites W1606409542 @default.
- W1940430771 cites W1735762627 @default.
- W1940430771 cites W1964253746 @default.
- W1940430771 cites W1965529594 @default.
- W1940430771 cites W1966723276 @default.
- W1940430771 cites W1966833487 @default.
- W1940430771 cites W1966928239 @default.
- W1940430771 cites W1967903543 @default.
- W1940430771 cites W1968620505 @default.
- W1940430771 cites W1968714309 @default.
- W1940430771 cites W1970706641 @default.
- W1940430771 cites W1972307267 @default.
- W1940430771 cites W1973879755 @default.
- W1940430771 cites W1974708640 @default.
- W1940430771 cites W1974890397 @default.
- W1940430771 cites W1974916178 @default.
- W1940430771 cites W1976292255 @default.
- W1940430771 cites W1976301079 @default.
- W1940430771 cites W1977617838 @default.
- W1940430771 cites W1978028702 @default.
- W1940430771 cites W1978592193 @default.
- W1940430771 cites W1984171359 @default.
- W1940430771 cites W1986360575 @default.
- W1940430771 cites W1987530377 @default.
- W1940430771 cites W1988333558 @default.
- W1940430771 cites W1989487746 @default.
- W1940430771 cites W1990355009 @default.
- W1940430771 cites W1991103421 @default.
- W1940430771 cites W1991690400 @default.
- W1940430771 cites W1993079403 @default.
- W1940430771 cites W1993446183 @default.
- W1940430771 cites W1993800044 @default.
- W1940430771 cites W1993976172 @default.
- W1940430771 cites W1996786959 @default.
- W1940430771 cites W1997113958 @default.
- W1940430771 cites W1997117872 @default.
- W1940430771 cites W1997611686 @default.
- W1940430771 cites W1998883267 @default.
- W1940430771 cites W1998964977 @default.
- W1940430771 cites W1999081109 @default.
- W1940430771 cites W1999951331 @default.
- W1940430771 cites W2000718394 @default.
- W1940430771 cites W2000736267 @default.
- W1940430771 cites W2002017977 @default.
- W1940430771 cites W2002403588 @default.
- W1940430771 cites W2004023429 @default.
- W1940430771 cites W2004214053 @default.
- W1940430771 cites W2004351764 @default.
- W1940430771 cites W2004920022 @default.
- W1940430771 cites W2005799364 @default.
- W1940430771 cites W2005958031 @default.
- W1940430771 cites W2005972406 @default.
- W1940430771 cites W2009399048 @default.
- W1940430771 cites W2009523739 @default.
- W1940430771 cites W2010286953 @default.
- W1940430771 cites W2012488166 @default.
- W1940430771 cites W2013166769 @default.
- W1940430771 cites W2014294449 @default.
- W1940430771 cites W2016738227 @default.
- W1940430771 cites W2016958205 @default.
- W1940430771 cites W2018316000 @default.
- W1940430771 cites W2020329015 @default.
- W1940430771 cites W2023695022 @default.
- W1940430771 cites W2023733568 @default.
- W1940430771 cites W2023843317 @default.
- W1940430771 cites W2025004309 @default.
- W1940430771 cites W2026597179 @default.
- W1940430771 cites W2027202090 @default.
- W1940430771 cites W2027520391 @default.
- W1940430771 cites W2029225125 @default.
- W1940430771 cites W2031020964 @default.
- W1940430771 cites W2032258002 @default.
- W1940430771 cites W2032497688 @default.
- W1940430771 cites W2032533558 @default.
- W1940430771 cites W2033062977 @default.
- W1940430771 cites W2033172247 @default.
- W1940430771 cites W2033468005 @default.
- W1940430771 cites W2034073944 @default.
- W1940430771 cites W2035113012 @default.
- W1940430771 cites W2035897455 @default.
- W1940430771 cites W2036364175 @default.
- W1940430771 cites W2036760739 @default.
- W1940430771 cites W2036932956 @default.
- W1940430771 cites W2037624113 @default.
- W1940430771 cites W2038506832 @default.
- W1940430771 cites W2039208569 @default.