FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1940536465> ?p ?o ?g. }

• W1940536465 endingPage "409" @default.
• W1940536465 startingPage "400" @default.
• W1940536465 abstract "Marek’s disease (MD) strain CVI988 is the most-protective commercially available vaccine against very virulent plus (vv ) Marek’s disease virus (MDV). However, its use in meat-type chickens has been controversial. While several countries have been using CVI988 for more than 40 yr, others do not authorize its use or it is restricted mainly to layers. The use of CVI988 in meat-type chickens will be necessary in the future in areas where other vaccine protocols fail. The objective of this study was to evaluate factors (vaccine dose, vaccine origin, chicken genetics, age and route of vaccination, and combination with other MD vaccines) influencing the efficacy of CVI988 against MD in meat-type chickens. Three animal experiments were conducted in which various vaccine protocols using CVI988 were tested for their protection against challenge with vv strain 648A by contact at day of age. Experiments 1 and 2 were to compare the efficacy of CVI988 vaccines from three different origins (CVI988-A, CVI988-B, and CVI988-C) and evaluate the effect of vaccine dose and chicken genetics. Experiment 3 was to evaluate the effect of adding CVI988 vaccine to various vaccine protocols using other MD vaccines of serotypes 2 (SB-1) and 3 (rHVT). Our results show that, regardless of the origin of the vaccine, protection against early challenge with 648A was good when vaccines were administered at a high dose (>3000 plaque-forming units [PFU]). Differences among vaccines, however, were detected even when using a high dose in experiment 2 (vaccine CVI988-B conferred higher protection than did CVI988-C) but not in Experiment 1 (CVI988-B was compared to CVI988-A). The use of a fixed low dose (2000 PFU) of vaccine resulted in reduction in protection, and such reduction was more remarkable when using CVI988-A. No statistically significant differences were found when we compared the efficacy of CVI988 in two different genetic lines of broiler chickens (G1 and G2). Vaccination protocols that included CVI988 had better protection than protocols that only included MD vaccines of serotypes 2 and 3. This was true regardless of the vaccine protocol used (CVI988/rHVT SB-1; CVI988 rHVT SB-1/None; rHVT SB-1/CVI988; wherein the vaccine before the slash (/) was administered in ovo at embryonation day 18 and the vaccine after the slash was administered at day of age, subcutaneously). When only vaccines of serotypes 2 and 3 were used, protection against early challenge with vv MDV was higher when vaccines were administered in ovo (rHVT SB-1/None) than if vaccines were administered at hatch (None/rHVT SB-1). Monitoring vaccine DNA load in feather pulp (FP) samples at 1 wk was used to monitor vaccination, and results showed that differences in vaccine replication exist among vaccines but such differences were not necessarily related to protection (r = 0.41, P > 0.05). Monitoring load of challenge MDV DNA in FP at 21 days was conducted, and results correlated (r = 0.85, P < 0.05) with the percentage of chickens with MD lesions at the termination of the study, confirming that early diagnosis is a very powerful tool with which to evaluate protection." @default.
• W1940536465 created "2016-06-24" @default.
• W1940536465 creator A5027675928 @default.
• W1940536465 creator A5045295351 @default.
• W1940536465 creator A5046368966 @default.
• W1940536465 creator A5058138260 @default.
• W1940536465 creator A5087178295 @default.
• W1940536465 date "2015-09-01" @default.
• W1940536465 modified "2023-09-29" @default.
• W1940536465 title "Evaluation of Factors Influencing Efficacy of Vaccine Strain CVI988 Against Marek’s Disease in Meat-Type Chickens" @default.
• W1940536465 cites W1968250589 @default.
• W1940536465 cites W1981075470 @default.
• W1940536465 cites W1993095739 @default.
• W1940536465 cites W1996578768 @default.
• W1940536465 cites W2013981117 @default.
• W1940536465 cites W2023475884 @default.
• W1940536465 cites W2026467532 @default.
• W1940536465 cites W2029449729 @default.
• W1940536465 cites W2045855468 @default.
• W1940536465 cites W2061860034 @default.
• W1940536465 cites W2070429838 @default.
• W1940536465 cites W2072115896 @default.
• W1940536465 cites W2075815425 @default.
• W1940536465 cites W2081347394 @default.
• W1940536465 cites W2093409933 @default.
• W1940536465 cites W2108217091 @default.
• W1940536465 cites W2110059232 @default.
• W1940536465 cites W2113284921 @default.
• W1940536465 cites W2118546614 @default.
• W1940536465 cites W2127201901 @default.
• W1940536465 cites W2132144737 @default.
• W1940536465 cites W2132931831 @default.
• W1940536465 cites W2140215721 @default.
• W1940536465 cites W2165660663 @default.
• W1940536465 cites W2171312954 @default.
• W1940536465 cites W2274313736 @default.
• W1940536465 cites W2290138168 @default.
• W1940536465 cites W2314592284 @default.
• W1940536465 cites W2322474324 @default.
• W1940536465 cites W4300795936 @default.
• W1940536465 doi "https://doi.org/10.1637/11085-040915-reg.1" @default.
• W1940536465 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26478159" @default.
• W1940536465 hasPublicationYear "2015" @default.
• W1940536465 type Work @default.
• W1940536465 sameAs 1940536465 @default.
• W1940536465 citedByCount "7" @default.
• W1940536465 countsByYear W19405364652016 @default.
• W1940536465 countsByYear W19405364652018 @default.
• W1940536465 countsByYear W19405364652019 @default.
• W1940536465 countsByYear W19405364652023 @default.
• W1940536465 crossrefType "journal-article" @default.
• W1940536465 hasAuthorship W1940536465A5027675928 @default.
• W1940536465 hasAuthorship W1940536465A5045295351 @default.
• W1940536465 hasAuthorship W1940536465A5046368966 @default.
• W1940536465 hasAuthorship W1940536465A5058138260 @default.
• W1940536465 hasAuthorship W1940536465A5087178295 @default.
• W1940536465 hasConcept C10389963 @default.
• W1940536465 hasConcept C104317684 @default.
• W1940536465 hasConcept C142724271 @default.
• W1940536465 hasConcept C159047783 @default.
• W1940536465 hasConcept C22070199 @default.
• W1940536465 hasConcept C2522874641 @default.
• W1940536465 hasConcept C2777852405 @default.
• W1940536465 hasConcept C2779134260 @default.
• W1940536465 hasConcept C2780441014 @default.
• W1940536465 hasConcept C42972112 @default.
• W1940536465 hasConcept C54355233 @default.
• W1940536465 hasConcept C60987743 @default.
• W1940536465 hasConcept C71924100 @default.
• W1940536465 hasConcept C86803240 @default.
• W1940536465 hasConceptScore W1940536465C10389963 @default.
• W1940536465 hasConceptScore W1940536465C104317684 @default.
• W1940536465 hasConceptScore W1940536465C142724271 @default.
• W1940536465 hasConceptScore W1940536465C159047783 @default.
• W1940536465 hasConceptScore W1940536465C22070199 @default.
• W1940536465 hasConceptScore W1940536465C2522874641 @default.
• W1940536465 hasConceptScore W1940536465C2777852405 @default.
• W1940536465 hasConceptScore W1940536465C2779134260 @default.
• W1940536465 hasConceptScore W1940536465C2780441014 @default.
• W1940536465 hasConceptScore W1940536465C42972112 @default.
• W1940536465 hasConceptScore W1940536465C54355233 @default.
• W1940536465 hasConceptScore W1940536465C60987743 @default.
• W1940536465 hasConceptScore W1940536465C71924100 @default.
• W1940536465 hasConceptScore W1940536465C86803240 @default.
• W1940536465 hasIssue "3" @default.
• W1940536465 hasLocation W19405364651 @default.
• W1940536465 hasLocation W19405364652 @default.
• W1940536465 hasOpenAccess W1940536465 @default.
• W1940536465 hasPrimaryLocation W19405364651 @default.
• W1940536465 hasRelatedWork W112997994 @default.
• W1940536465 hasRelatedWork W1996763369 @default.
• W1940536465 hasRelatedWork W2040189101 @default.
• W1940536465 hasRelatedWork W2049127623 @default.
• W1940536465 hasRelatedWork W2062437448 @default.
• W1940536465 hasRelatedWork W2301361001 @default.
• W1940536465 hasRelatedWork W2314592284 @default.
• W1940536465 hasRelatedWork W2356149825 @default.
• W1940536465 hasRelatedWork W2408900517 @default.

• next