FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1940550010> ?p ?o ?g. }

• W1940550010 endingPage "63" @default.
• W1940550010 startingPage "2157" @default.
• W1940550010 abstract "The present treatment of colon cancer is based on 5-fluorouracil (5-FU). Despite promising results of combining leucovorin or levamisole with 5-FU, the 5-year survival rate of patients with advanced colon cancer has not increased significantly. Colon tumors in vitro have been shown previously to have an elevated requirement for methionine, suggesting a new therapeutic target. In this study, targeting the methionine dependence of colon tumors is effected by recombinant methioninase (rMETase), alone and in combination with cisplatin (CDDP). In vitro results demonstrated that CDDP and rMETase act synergistically on the human colon cancer cell line SW 620, with a combination index (CI) of 0.45, as well as on the human colon cancer cell line Colo 205 with a CI of 0.7. Human colon cancer lines HCT 15, HT 29, Colo 205, and SW 620 growing in nude mice were treated with rMETase to determine an effective dose for depletion of tumor methionine. rMETase at 15 units/g/day for 5 days depleted tumor methionine in all four tumor types to approximately 30% of untreated control. rMETase alone arrested growth of HCT 15 and HT29 in nude mice for 1 week after treatment termination. Colo 205 and SW 620 were partially arrested by rMETase. However, CDDP in combination with rMETase resulted in tumor regression of Colo 205 and growth arrest of SW 620 in nude mice. The ratio of the treated:control group (T:C) tumor weights for Colo 205 was 8% when CDDP was given on day-5, followed by treatment on days 5-9 with rMETase. This treatment schedule resulted in two of the six animals having no detectable tumor when the experiment was terminated on day 16. SW620 was resistant to CDDP alone and only partially sensitive to rMETase alone. However, when SW 620 was treated with rMETase from days-5 to -9 and CDDP on day-5, tumor growth was arrested. The results demonstrate that rMETase used simultaneously in combination with CDDP had significant antitumor efficacy in colon cancer in vitro and in vivo. The data suggest a novel and promising therapeutic approach by targeting the elevated methionine dependence of colon cancer." @default.
• W1940550010 created "2016-06-24" @default.
• W1940550010 creator A5005261216 @default.
• W1940550010 creator A5020742853 @default.
• W1940550010 creator A5027210710 @default.
• W1940550010 creator A5032267305 @default.
• W1940550010 creator A5040819666 @default.
• W1940550010 creator A5071773097 @default.
• W1940550010 creator A5080531373 @default.
• W1940550010 creator A5083466095 @default.
• W1940550010 creator A5085854173 @default.
• W1940550010 creator A5088171227 @default.
• W1940550010 creator A5090025086 @default.
• W1940550010 date "1999-08-01" @default.
• W1940550010 modified "2023-10-01" @default.
• W1940550010 title "Efficacy of recombinant methioninase in combination with cisplatin on human colon tumors in nude mice." @default.
• W1940550010 cites W1530556189 @default.
• W1940550010 cites W1544424898 @default.
• W1940550010 cites W1581942310 @default.
• W1940550010 cites W1751468981 @default.
• W1940550010 cites W1844255926 @default.
• W1940550010 cites W1964767242 @default.
• W1940550010 cites W1974960081 @default.
• W1940550010 cites W1993537854 @default.
• W1940550010 cites W1999839653 @default.
• W1940550010 cites W2000710160 @default.
• W1940550010 cites W2014252256 @default.
• W1940550010 cites W2018589424 @default.
• W1940550010 cites W2036409540 @default.
• W1940550010 cites W2051834111 @default.
• W1940550010 cites W2052357987 @default.
• W1940550010 cites W2057881489 @default.
• W1940550010 cites W2081193330 @default.
• W1940550010 cites W2106803769 @default.
• W1940550010 cites W2107117572 @default.
• W1940550010 cites W2122134113 @default.
• W1940550010 cites W2136507498 @default.
• W1940550010 cites W2154358880 @default.
• W1940550010 cites W2163876716 @default.
• W1940550010 cites W2396466397 @default.
• W1940550010 cites W2413625537 @default.
• W1940550010 cites W2417563017 @default.
• W1940550010 cites W2418346118 @default.
• W1940550010 cites W25117316 @default.
• W1940550010 cites W279302623 @default.
• W1940550010 cites W35486502 @default.
• W1940550010 cites W3719474 @default.
• W1940550010 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10473100" @default.
• W1940550010 hasPublicationYear "1999" @default.
• W1940550010 type Work @default.
• W1940550010 sameAs 1940550010 @default.
• W1940550010 citedByCount "44" @default.
• W1940550010 countsByYear W19405500102012 @default.
• W1940550010 countsByYear W19405500102014 @default.
• W1940550010 countsByYear W19405500102015 @default.
• W1940550010 countsByYear W19405500102016 @default.
• W1940550010 countsByYear W19405500102017 @default.
• W1940550010 countsByYear W19405500102018 @default.
• W1940550010 countsByYear W19405500102019 @default.
• W1940550010 countsByYear W19405500102020 @default.
• W1940550010 countsByYear W19405500102022 @default.
• W1940550010 countsByYear W19405500102023 @default.
• W1940550010 crossrefType "journal-article" @default.
• W1940550010 hasAuthorship W1940550010A5005261216 @default.
• W1940550010 hasAuthorship W1940550010A5020742853 @default.
• W1940550010 hasAuthorship W1940550010A5027210710 @default.
• W1940550010 hasAuthorship W1940550010A5032267305 @default.
• W1940550010 hasAuthorship W1940550010A5040819666 @default.
• W1940550010 hasAuthorship W1940550010A5071773097 @default.
• W1940550010 hasAuthorship W1940550010A5080531373 @default.
• W1940550010 hasAuthorship W1940550010A5083466095 @default.
• W1940550010 hasAuthorship W1940550010A5085854173 @default.
• W1940550010 hasAuthorship W1940550010A5088171227 @default.
• W1940550010 hasAuthorship W1940550010A5090025086 @default.
• W1940550010 hasConcept C121608353 @default.
• W1940550010 hasConcept C126322002 @default.
• W1940550010 hasConcept C143998085 @default.
• W1940550010 hasConcept C150903083 @default.
• W1940550010 hasConcept C202751555 @default.
• W1940550010 hasConcept C207001950 @default.
• W1940550010 hasConcept C2776694085 @default.
• W1940550010 hasConcept C2778239845 @default.
• W1940550010 hasConcept C2780456651 @default.
• W1940550010 hasConcept C2780912031 @default.
• W1940550010 hasConcept C502942594 @default.
• W1940550010 hasConcept C515207424 @default.
• W1940550010 hasConcept C526805850 @default.
• W1940550010 hasConcept C54355233 @default.
• W1940550010 hasConcept C55493867 @default.
• W1940550010 hasConcept C71924100 @default.
• W1940550010 hasConcept C81885089 @default.
• W1940550010 hasConcept C86803240 @default.
• W1940550010 hasConcept C98274493 @default.
• W1940550010 hasConceptScore W1940550010C121608353 @default.
• W1940550010 hasConceptScore W1940550010C126322002 @default.
• W1940550010 hasConceptScore W1940550010C143998085 @default.
• W1940550010 hasConceptScore W1940550010C150903083 @default.
• W1940550010 hasConceptScore W1940550010C202751555 @default.

• next