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• W1940626095 endingPage "879" @default.
• W1940626095 startingPage "868" @default.
• W1940626095 abstract "After 7/8 nephrectomy, the remnant kidney exhibits an adaptive increase in acid secretion per nephron. We studied the role of the kidney vacuolar H(+)-ATPase in this adaptational response by anti-H(+)-ATPase immunocytochemistry in kidneys from rats subjected to 7/8 nephrectomy or a sham procedure at 1, 2, and 3 wk after surgery. No changes in H(+)-ATPase staining were apparent in the proximal tubule, thick ascending limb, or distal convoluted tubule. In the cortical collecting ducts, the percentage of intercalated cells with well-polarized apical and well-polarized basolateral H(+)-ATPase staining was significantly higher in the remnant kidneys at 1, 2, and 3 wk. In the medullary intercalated cells of the sham-operated kidneys, relatively few cells had predominant plasma membrane H(+)-ATPase staining. In the remnant kidneys, the percentage of medullary intercalated cells with predominant plasma membrane H(+)-ATPase staining was increased significantly at 1 and 2 wk after surgery, returning to sham-operated values at 3 wk. The results indicate that intercalated cells in the collecting ducts of both cortex and medulla participate in the adaptation to reduction in renal mass by changing the steady-state distribution of H(+)-ATPase, similar to changes that occur with chronic acid administration." @default.
• W1940626095 created "2016-06-24" @default.
• W1940626095 creator A5053658081 @default.
• W1940626095 creator A5074854171 @default.
• W1940626095 date "1997-06-01" @default.
• W1940626095 modified "2023-10-13" @default.
• W1940626095 title "Adaptational changes in renal vacuolar H(+)-ATPase in the rat remnant kidney." @default.
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• W1940626095 doi "https://doi.org/10.1681/asn.v86868" @default.
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