Matches in SemOpenAlex for { <https://semopenalex.org/work/W1940634245> ?p ?o ?g. }
- W1940634245 abstract "The response of colorectal tumours to chemotherapy is highly variable. Preclinical work has shown that the Kirsten ras (KRAS) oncogene sensitizes colorectal tumour cells to oxaliplatin and capecitabine in a wild-type tumour suppressor p53 (TP53)-dependent manner. Therefore, whether or not the combined mutation status of KRAS and TP53 could predict response to chemotherapy in metastatic colorectal cancer was tested.A subgroup of patients from the CAIRO2 study (randomized phase III study on capecitabine, oxaliplatin, bevacizumab with or without cetuximab in first-line advanced colorectal cancer) that received capecitabine plus oxaliplatin (CAPOX) treatment in combination with bevacizumab was selected. The tumours were analyzed for KRAS and TP53 mutations by PCR/sequencing. The relationship between tumour response and genotype was analyzed.The following KRAS/TP53 genotypes were identified: KRASmut/TP53mut n=21, KRASmut/TP53wt n=20, KRASwt/TP53mut n=25, KRASwt/TP53wt n=15. No genotype was associated with a significantly better or worse progression-free or overall survival.The combined mutation status of KRAS and TP53 does not predict response to CAPOX in patients with metastasized colorectal cancer." @default.
- W1940634245 created "2016-06-24" @default.
- W1940634245 creator A5004575257 @default.
- W1940634245 creator A5008547755 @default.
- W1940634245 creator A5015277595 @default.
- W1940634245 creator A5034755473 @default.
- W1940634245 creator A5037625836 @default.
- W1940634245 creator A5043942519 @default.
- W1940634245 creator A5061097704 @default.
- W1940634245 creator A5068038653 @default.
- W1940634245 date "2011-04-01" @default.
- W1940634245 modified "2023-10-12" @default.
- W1940634245 title "Combined KRAS and TP53 mutation status is not predictive in CAPOX-treated metastatic colorectal cancer." @default.
- W1940634245 cites W1970221755 @default.
- W1940634245 cites W1975877744 @default.
- W1940634245 cites W1986076152 @default.
- W1940634245 cites W2000452401 @default.
- W1940634245 cites W2004072274 @default.
- W1940634245 cites W2005943210 @default.
- W1940634245 cites W2008374616 @default.
- W1940634245 cites W2055262549 @default.
- W1940634245 cites W2076699783 @default.
- W1940634245 cites W2095680213 @default.
- W1940634245 cites W2114455364 @default.
- W1940634245 cites W2119050414 @default.
- W1940634245 cites W2123611321 @default.
- W1940634245 cites W2126162016 @default.
- W1940634245 cites W2127640925 @default.
- W1940634245 cites W2141609698 @default.
- W1940634245 cites W2144963939 @default.
- W1940634245 cites W2148953497 @default.
- W1940634245 cites W2162313061 @default.
- W1940634245 cites W2165976417 @default.
- W1940634245 cites W2120627772 @default.
- W1940634245 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21508389" @default.
- W1940634245 hasPublicationYear "2011" @default.
- W1940634245 type Work @default.
- W1940634245 sameAs 1940634245 @default.
- W1940634245 citedByCount "3" @default.
- W1940634245 countsByYear W19406342452016 @default.
- W1940634245 countsByYear W19406342452017 @default.
- W1940634245 countsByYear W19406342452019 @default.
- W1940634245 crossrefType "journal-article" @default.
- W1940634245 hasAuthorship W1940634245A5004575257 @default.
- W1940634245 hasAuthorship W1940634245A5008547755 @default.
- W1940634245 hasAuthorship W1940634245A5015277595 @default.
- W1940634245 hasAuthorship W1940634245A5034755473 @default.
- W1940634245 hasAuthorship W1940634245A5037625836 @default.
- W1940634245 hasAuthorship W1940634245A5043942519 @default.
- W1940634245 hasAuthorship W1940634245A5061097704 @default.
- W1940634245 hasAuthorship W1940634245A5068038653 @default.
- W1940634245 hasConcept C121608353 @default.
- W1940634245 hasConcept C126322002 @default.
- W1940634245 hasConcept C143998085 @default.
- W1940634245 hasConcept C2776694085 @default.
- W1940634245 hasConcept C2777802072 @default.
- W1940634245 hasConcept C2777909004 @default.
- W1940634245 hasConcept C2779998722 @default.
- W1940634245 hasConcept C2780962732 @default.
- W1940634245 hasConcept C2781187634 @default.
- W1940634245 hasConcept C502942594 @default.
- W1940634245 hasConcept C526805850 @default.
- W1940634245 hasConcept C71924100 @default.
- W1940634245 hasConceptScore W1940634245C121608353 @default.
- W1940634245 hasConceptScore W1940634245C126322002 @default.
- W1940634245 hasConceptScore W1940634245C143998085 @default.
- W1940634245 hasConceptScore W1940634245C2776694085 @default.
- W1940634245 hasConceptScore W1940634245C2777802072 @default.
- W1940634245 hasConceptScore W1940634245C2777909004 @default.
- W1940634245 hasConceptScore W1940634245C2779998722 @default.
- W1940634245 hasConceptScore W1940634245C2780962732 @default.
- W1940634245 hasConceptScore W1940634245C2781187634 @default.
- W1940634245 hasConceptScore W1940634245C502942594 @default.
- W1940634245 hasConceptScore W1940634245C526805850 @default.
- W1940634245 hasConceptScore W1940634245C71924100 @default.
- W1940634245 hasLocation W19406342451 @default.
- W1940634245 hasOpenAccess W1940634245 @default.
- W1940634245 hasPrimaryLocation W19406342451 @default.
- W1940634245 hasRelatedWork W1510514013 @default.
- W1940634245 hasRelatedWork W1967470942 @default.
- W1940634245 hasRelatedWork W1989028927 @default.
- W1940634245 hasRelatedWork W2004726560 @default.
- W1940634245 hasRelatedWork W2011492006 @default.
- W1940634245 hasRelatedWork W2024761986 @default.
- W1940634245 hasRelatedWork W2028035144 @default.
- W1940634245 hasRelatedWork W2056658990 @default.
- W1940634245 hasRelatedWork W2097709626 @default.
- W1940634245 hasRelatedWork W2118613906 @default.
- W1940634245 hasRelatedWork W2122618533 @default.
- W1940634245 hasRelatedWork W2125229905 @default.
- W1940634245 hasRelatedWork W2135800465 @default.
- W1940634245 hasRelatedWork W2138970634 @default.
- W1940634245 hasRelatedWork W2150840254 @default.
- W1940634245 hasRelatedWork W2152490158 @default.
- W1940634245 hasRelatedWork W2164837623 @default.
- W1940634245 hasRelatedWork W2168034599 @default.
- W1940634245 hasRelatedWork W2269104115 @default.
- W1940634245 hasRelatedWork W2271939653 @default.
- W1940634245 isParatext "false" @default.
- W1940634245 isRetracted "false" @default.