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• W1940638574 abstract "Ubiquitin-B+1 (UBB+1) is a mutant ubiquitin that accumulates in the neurones of patients with Alzheimer's disease (AD). Here we report on the biochemical and functional differences between ubiquitin and UBB+1 and the effect of the mutant protein on neuronal cells. UBB+1 lacks the capacity to ubiquitinate, and although it is ubiquitinated itself, UBB+1 is not degraded by the ubiquitin-proteasomal system and is quite stable in neuronal cells. Overexpression of UBB+1 in neuroblastoma cells significantly induces nuclear fragmentation and cell death. Our results demonstrate that accumulation of UBB+1 in neurones is detrimental and may contribute to neuronal dysfunction in AD patients." @default.
• W1940638574 created "2016-06-24" @default.
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• W1940638574 date "2001-12-01" @default.
• W1940638574 modified "2023-10-12" @default.
• W1940638574 title "Mutant ubiquitin expressed in Alzheimer's disease causes neuronal death¹" @default.
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• W1940638574 doi "https://doi.org/10.1096/fj.01-0438com" @default.
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