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- W1940763458 abstract "Two peptides of Pt-A (Glu-Asn-Trp 429 Da) and Pt-B (Glu-Gln-Trp 443 Da) were isolated from venom liquor of Deinagkistrodon acutus . Their antiplatelet aggregation effects were evaluated with platelet-rich human plasma in vitro ; the respective IC 50 of Pt-A and Pt-B was 66 μ M and 203 μ M. Both peptides exhibited protection effects on ADP-induced paralysis in mice. After ADP administration, the paralysis time of different concentration of Pt-A and Pt-B lasted as the following: 80 mg/kg Pt-B (152.8 ± 57.8 s) < 40 mg/kg Pt-A (163.5 ± 59.8 s) < 20 mg/kg Pt-A (253.5 ± 74.5 s) < 4 mg/kg clopidogrel (a positive control, 254.5 ± 41.97 s) < 40 mg/kg Pt-B (400.8 ± 35.9 s) < 10 mg/kg Pt-A (422.8 ± 55.4 s), all of which were statistically shorter than the saline treatment (666 ± 28 s). Pulmonary tissue biopsy confirmed that Pt-A and Pt-B prevented the formation of thrombi in the lung. Unlike ADP injection alone, which caused significant reduction of peripheral platelet count, Pt-A treatment prevented the drop of peripheral platelet counts; interestingly, Pt-B could not, even though the same amount of Pt-B also showed protection effects on ADP-induced paralysis and thrombosis. More importantly, intravenous injection of Pt-A and Pt-B did not significantly increase the hemorrhage risks as clopidogrel." @default.
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- W1940763458 date "2015-01-01" @default.
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- W1940763458 title "Antiplatelet Aggregation and Antithrombosis Efficiency of Peptides in the Snake Venom of<i>Deinagkistrodon acutus</i>: Isolation, Identification, and Evaluation" @default.
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- W1940763458 doi "https://doi.org/10.1155/2015/412841" @default.
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