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- W1940779870 abstract "At early embryonic stages, zebrafish spinal neuron subtypes can be distinguished and accessed for physiological studies. This provides the opportunity to determine electrophysiological properties of different spinal motor neuron subtypes. Such differences have the potential to then regulate, in a subtype‐specific manner, activity‐dependent developmental events such as axonal outgrowth and pathfinding. The zebrafish spinal cord contains a population of early born neurons. Our recent work has revealed that primary motor neuron (PMN) subtypes in the zebrafish spinal cord differ with respect to electrical properties during early important periods when PMNs extend axons to their specific targets. Here, we review recent findings regarding the development of electrical properties in PMN subtypes. Moreover, we consider the possibility that electrical activity in PMNs may play a cell nonautonomous role and thus influence the development of later developing motor neurons. Further, we discuss findings that support a role for a specific sodium channel isoform, Nav1.6, expressed by specific subtypes of spinal neurons in activity‐dependent processes that impact axonal outgrowth and pathfinding." @default.
- W1940779870 created "2016-06-24" @default.
- W1940779870 creator A5031299935 @default.
- W1940779870 creator A5035950888 @default.
- W1940779870 date "2010-06-01" @default.
- W1940779870 modified "2023-09-27" @default.
- W1940779870 title "Developmental regulation of subtype-specific motor neuron excitability" @default.
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- W1940779870 doi "https://doi.org/10.1111/j.1749-6632.2009.05426.x" @default.
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