FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1940955820> ?p ?o ?g. }

• W1940955820 endingPage "1070" @default.
• W1940955820 startingPage "1059" @default.
• W1940955820 abstract "Abstract The Ras signaling pathway in Saccharomyces cerevisiae controls cell growth via the cAMP-dependent protein kinase, PKA. Recent work has indicated that these effects on growth are due, in part, to the regulation of activities associated with the C-terminal domain (CTD) of the largest subunit of RNA polymerase II. However, the precise target of these Ras effects has remained unknown. This study suggests that Ras/PKA activity regulates the elongation step of the RNA polymerase II transcription process. Several lines of evidence indicate that Spt5p in the Spt4p/Spt5p elongation factor is the likely target of this control. First, the growth of spt4 and spt5 mutants was found to be very sensitive to changes in Ras/PKA signaling activity. Second, mutants with elevated levels of Ras activity shared a number of specific phenotypes with spt5 mutants and vice versa. Finally, Spt5p was efficiently phosphorylated by PKA in vitro. Altogether, the data suggest that the Ras/PKA pathway might be directly targeting a component of the elongating polymerase complex and that this regulation is important for the normal control of yeast cell growth. These data point out the interesting possibility that signal transduction pathways might directly influence the elongation step of RNA polymerase II transcription." @default.
• W1940955820 created "2016-06-24" @default.
• W1940955820 creator A5002329809 @default.
• W1940955820 creator A5014707802 @default.
• W1940955820 creator A5050951546 @default.
• W1940955820 date "2003-11-01" @default.
• W1940955820 modified "2023-10-18" @default.
• W1940955820 title "The Ras/PKA Signaling Pathway May Control RNA Polymerase II Elongation via the Spt4p/Spt5p Complex in <i>Saccharomyces cerevisiae</i>" @default.
• W1940955820 cites W1516081056 @default.
• W1940955820 cites W1554851690 @default.
• W1940955820 cites W1805450297 @default.
• W1940955820 cites W1899174876 @default.
• W1940955820 cites W1965977492 @default.
• W1940955820 cites W1973423104 @default.
• W1940955820 cites W1973604371 @default.
• W1940955820 cites W1973608892 @default.
• W1940955820 cites W1974605099 @default.
• W1940955820 cites W1977627171 @default.
• W1940955820 cites W1984770675 @default.
• W1940955820 cites W1993364986 @default.
• W1940955820 cites W1995733973 @default.
• W1940955820 cites W1997260371 @default.
• W1940955820 cites W1998326358 @default.
• W1940955820 cites W1999441881 @default.
• W1940955820 cites W2002085309 @default.
• W1940955820 cites W2003168089 @default.
• W1940955820 cites W2004617021 @default.
• W1940955820 cites W2007061743 @default.
• W1940955820 cites W2008014792 @default.
• W1940955820 cites W2012475101 @default.
• W1940955820 cites W2013824955 @default.
• W1940955820 cites W2014656185 @default.
• W1940955820 cites W2020329201 @default.
• W1940955820 cites W2033680244 @default.
• W1940955820 cites W2036244319 @default.
• W1940955820 cites W2036970927 @default.
• W1940955820 cites W2041101605 @default.
• W1940955820 cites W2044793296 @default.
• W1940955820 cites W2048404380 @default.
• W1940955820 cites W2058565051 @default.
• W1940955820 cites W2061314148 @default.
• W1940955820 cites W2061572889 @default.
• W1940955820 cites W2061784731 @default.
• W1940955820 cites W2062630554 @default.
• W1940955820 cites W2065029409 @default.
• W1940955820 cites W2067953727 @default.
• W1940955820 cites W2068479879 @default.
• W1940955820 cites W2071674961 @default.
• W1940955820 cites W2072459861 @default.
• W1940955820 cites W2080910217 @default.
• W1940955820 cites W2080993511 @default.
• W1940955820 cites W2083804862 @default.
• W1940955820 cites W2085631727 @default.
• W1940955820 cites W2086137592 @default.
• W1940955820 cites W2087198110 @default.
• W1940955820 cites W2088058526 @default.
• W1940955820 cites W2089108869 @default.
• W1940955820 cites W2092594895 @default.
• W1940955820 cites W2092937197 @default.
• W1940955820 cites W2099898735 @default.
• W1940955820 cites W2102678326 @default.
• W1940955820 cites W2103626942 @default.
• W1940955820 cites W2105192976 @default.
• W1940955820 cites W2105721989 @default.
• W1940955820 cites W2107635128 @default.
• W1940955820 cites W2108422586 @default.
• W1940955820 cites W2108458500 @default.
• W1940955820 cites W2111646262 @default.
• W1940955820 cites W2116384789 @default.
• W1940955820 cites W2119024534 @default.
• W1940955820 cites W2126730534 @default.
• W1940955820 cites W2128098474 @default.
• W1940955820 cites W2141373343 @default.
• W1940955820 cites W2148917483 @default.
• W1940955820 cites W2160709235 @default.
• W1940955820 cites W2165289894 @default.
• W1940955820 cites W2167331352 @default.
• W1940955820 cites W2169333620 @default.
• W1940955820 cites W2170092320 @default.
• W1940955820 cites W2171171901 @default.
• W1940955820 cites W2173344695 @default.
• W1940955820 doi "https://doi.org/10.1093/genetics/165.3.1059" @default.
• W1940955820 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1462858" @default.
• W1940955820 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14668364" @default.
• W1940955820 hasPublicationYear "2003" @default.
• W1940955820 type Work @default.
• W1940955820 sameAs 1940955820 @default.
• W1940955820 citedByCount "24" @default.
• W1940955820 countsByYear W19409558202012 @default.
• W1940955820 countsByYear W19409558202013 @default.
• W1940955820 countsByYear W19409558202014 @default.
• W1940955820 countsByYear W19409558202016 @default.
• W1940955820 countsByYear W19409558202017 @default.
• W1940955820 countsByYear W19409558202018 @default.
• W1940955820 crossrefType "journal-article" @default.
• W1940955820 hasAuthorship W1940955820A5002329809 @default.
• W1940955820 hasAuthorship W1940955820A5014707802 @default.
• W1940955820 hasAuthorship W1940955820A5050951546 @default.

• next