FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1941055066> ?p ?o ?g. }

• W1941055066 endingPage "160" @default.
• W1941055066 startingPage "152" @default.
• W1941055066 abstract "Objective To examine hormone receptor expression levels and downstream gene activation in pre-treatment and post-treatment biopsies in a cohort of patients with endometrial pathology who were being conservatively managed with a progestin-containing intrauterine device (IUD). A molecular signature of treatment failure is proposed. Methods A retrospective analysis of pre- and post-treatment biopsy specimens from 10 women treated with progestin-containing IUD for complex atypical hyperplasia (CAH) or grade 1 endometrioid adenocarcinoma was performed. Expression of estrogen receptor (ER), progesterone receptor (PR) and PR target genes was examined by immunohistochemistry (IHC) and quantitative RT-PCR. Results The mean treatment duration was 14.3 months. Four CAH patients had stable disease or regressed after treatment, and four progressed to endometrioid adenocarcinoma. Both patients with an initial diagnosis of endometrioid adenocarcinoma regressed to CAH or no disease. In general, hormone receptor levels diminished post-treatment compared to pre-treatment biopsies; however, we noted unexpected higher expression of the B isoform of PR (PRB) as well as ER in those patients who progressed to frank cancer. There was a trend towards a non-nuclear cytoplasmic location of PRB in these patients. Importantly, the differentiating impact of PR signaling, as determined by the expression of the progestin-controlled tumor suppressor FOXO1, was lost in individuals who progressed on therapy. Conclusions FOXO1 mRNA levels may serve as a biomarker for response to therapy and an indicator of PR function in patients being conservatively managed with a progestin-containing IUD." @default.
• W1941055066 created "2016-06-24" @default.
• W1941055066 creator A5000348773 @default.
• W1941055066 creator A5009733542 @default.
• W1941055066 creator A5018932514 @default.
• W1941055066 creator A5022391052 @default.
• W1941055066 creator A5027726811 @default.
• W1941055066 creator A5031164821 @default.
• W1941055066 creator A5033621036 @default.
• W1941055066 creator A5034340864 @default.
• W1941055066 creator A5043390661 @default.
• W1941055066 creator A5045245691 @default.
• W1941055066 creator A5064907038 @default.
• W1941055066 creator A5075341219 @default.
• W1941055066 creator A5088579856 @default.
• W1941055066 date "2016-01-01" @default.
• W1941055066 modified "2023-10-16" @default.
• W1941055066 title "Downregulation of FOXO1 mRNA levels predicts treatment failure in patients with endometrial pathology conservatively managed with progestin-containing intrauterine devices" @default.
• W1941055066 cites W1834297004 @default.
• W1941055066 cites W186316921 @default.
• W1941055066 cites W1968400287 @default.
• W1941055066 cites W1986840948 @default.
• W1941055066 cites W1986896421 @default.
• W1941055066 cites W1992111987 @default.
• W1941055066 cites W1996332755 @default.
• W1941055066 cites W1996610137 @default.
• W1941055066 cites W1997038527 @default.
• W1941055066 cites W2006156792 @default.
• W1941055066 cites W2017905340 @default.
• W1941055066 cites W2021021306 @default.
• W1941055066 cites W2023879626 @default.
• W1941055066 cites W2024827041 @default.
• W1941055066 cites W2026144478 @default.
• W1941055066 cites W2041440766 @default.
• W1941055066 cites W2047111383 @default.
• W1941055066 cites W2050276596 @default.
• W1941055066 cites W2052648972 @default.
• W1941055066 cites W2058917128 @default.
• W1941055066 cites W2064617101 @default.
• W1941055066 cites W2067208421 @default.
• W1941055066 cites W2067620958 @default.
• W1941055066 cites W2069547854 @default.
• W1941055066 cites W2095820703 @default.
• W1941055066 cites W2097113048 @default.
• W1941055066 cites W2107277218 @default.
• W1941055066 cites W2114570899 @default.
• W1941055066 cites W2131101565 @default.
• W1941055066 cites W2137035181 @default.
• W1941055066 cites W2157371671 @default.
• W1941055066 cites W2192080449 @default.
• W1941055066 cites W2322185431 @default.
• W1941055066 cites W2411984274 @default.
• W1941055066 cites W4241756178 @default.
• W1941055066 doi "https://doi.org/10.1016/j.ygyno.2015.10.023" @default.
• W1941055066 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4784706" @default.
• W1941055066 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26524723" @default.
• W1941055066 hasPublicationYear "2016" @default.
• W1941055066 type Work @default.
• W1941055066 sameAs 1941055066 @default.
• W1941055066 citedByCount "19" @default.
• W1941055066 countsByYear W19410550662017 @default.
• W1941055066 countsByYear W19410550662018 @default.
• W1941055066 countsByYear W19410550662019 @default.
• W1941055066 countsByYear W19410550662020 @default.
• W1941055066 countsByYear W19410550662021 @default.
• W1941055066 countsByYear W19410550662022 @default.
• W1941055066 countsByYear W19410550662023 @default.
• W1941055066 crossrefType "journal-article" @default.
• W1941055066 hasAuthorship W1941055066A5000348773 @default.
• W1941055066 hasAuthorship W1941055066A5009733542 @default.
• W1941055066 hasAuthorship W1941055066A5018932514 @default.
• W1941055066 hasAuthorship W1941055066A5022391052 @default.
• W1941055066 hasAuthorship W1941055066A5027726811 @default.
• W1941055066 hasAuthorship W1941055066A5031164821 @default.
• W1941055066 hasAuthorship W1941055066A5033621036 @default.
• W1941055066 hasAuthorship W1941055066A5034340864 @default.
• W1941055066 hasAuthorship W1941055066A5043390661 @default.
• W1941055066 hasAuthorship W1941055066A5045245691 @default.
• W1941055066 hasAuthorship W1941055066A5064907038 @default.
• W1941055066 hasAuthorship W1941055066A5075341219 @default.
• W1941055066 hasAuthorship W1941055066A5088579856 @default.
• W1941055066 hasBestOaLocation W19410550662 @default.
• W1941055066 hasConcept C121608353 @default.
• W1941055066 hasConcept C126322002 @default.
• W1941055066 hasConcept C143998085 @default.
• W1941055066 hasConcept C204232928 @default.
• W1941055066 hasConcept C2775904963 @default.
• W1941055066 hasConcept C2775934546 @default.
• W1941055066 hasConcept C2776606343 @default.
• W1941055066 hasConcept C2776607906 @default.
• W1941055066 hasConcept C2777088508 @default.
• W1941055066 hasConcept C2777164284 @default.
• W1941055066 hasConcept C2779742232 @default.
• W1941055066 hasConcept C2781182431 @default.
• W1941055066 hasConcept C530470458 @default.
• W1941055066 hasConcept C71924100 @default.
• W1941055066 hasConcept C84606932 @default.
• W1941055066 hasConcept C98717036 @default.

• next