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- W1941136548 abstract "The inhibition of mineralocorticoid receptor (MR) prevents progression of renal and cardiac fibrosis. MR is also present in the lung, and thus we hypothesized that persistent inappropriate activation of mineralocorticoid receptor potentiates lung fibrosis, which can be prevented by mineralocorticoid receptor antagonism. Lung fibrosis in Sprague-Dawley rats induced by intraperitoneal paraquat (20 mg/kg) in saline 6 spironolactone therapy was evaluated. Control animals received intraperitoneal saline vehicle6 spironolactone. Sham surgery or subcutaneous implantation of a spironolactone pellet (200 mg; 60-d release) was done 1 week before exposure. Animals were killed 4 weeks after paraquat exposure. Lung lavage was collected. One lung was frozen in liquid nitrogen for hydroxyproline assay (OHproline); the other was inflated with fixative for 24 hours, and then processed for histology and Picrosirius staining for collagen. Results are shown in Table 1. Twenty eight days after injury due to paraquat exposure, the lungs of rats with no MR antagonist treatment showed significant fibrosis, while those treated with spironolactone were not significantly different from the vehicle-treated rats. This suggests that MR activation mediates fibrosis in the lungs, as well as in the heart and kidney." @default.
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- W1941136548 date "2012-12-20" @default.
- W1941136548 modified "2023-09-28" @default.
- W1941136548 title "Extracellular Superoxide Induces Egr-1 and Promotes Hypoxic Pulmonary Vascular Remodeling" @default.
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