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• W1941145541 abstract "FUS, a nuclear RNA-binding protein, plays multiple roles in RNA processing. Five specific FUS-binding RNA sequence/structure motifs have been proposed, but their affinities for FUS have not been directly compared. Here we find that human FUS binds all these sequences with Kd (app) values spanning a 10-fold range. Furthermore, some RNAs that do not contain any of these motifs bind FUS with similar affinity. FUS binds RNA in a length-dependent manner, consistent with a substantial non-specific component to binding. Finally, investigation of FUS binding to different nucleic acids shows that it binds single-stranded DNA with three-fold lower affinity than ssRNA of the same length and sequence, while binding to double-stranded nucleic acids is weaker. We conclude that FUS has quite general nucleic acid-binding activity, with the various proposed RNA motifs being neither necessary for FUS binding nor sufficient to explain its diverse binding partners." @default.
• W1941145541 created "2016-06-24" @default.
• W1941145541 creator A5017573996 @default.
• W1941145541 creator A5034387325 @default.
• W1941145541 creator A5081014378 @default.
• W1941145541 date "2015-07-06" @default.
• W1941145541 modified "2023-10-14" @default.
• W1941145541 title "Nucleic acid-binding specificity of human FUS protein" @default.
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• W1941145541 doi "https://doi.org/10.1093/nar/gkv679" @default.
• W1941145541 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4551922" @default.
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