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- W1941175183 abstract "Abstract LPS endotoxin-induced macrophage activation is recognized to be important in both nonspecific immunity and endotoxin-induced sepsis when excessive macrophage stimulation occurs. In this study, we showed that reduction of c-Abl in macrophages prevented LPS-induced growth arrest, nitric oxide production and TNF-α secretion by ANA-1 macrophages. These cells continued to grow but later underwent apoptosis. Reduction of c-Abl in these cells led to reduced c-Abl kinase activity associated with Ran, which recently has been shown to be an LPS-responsive gene product. Our data suggest that c-Abl tyrosine kinase is one of the intermediates downstream of the initial signal transduction event related to activation of macrophages by LPS." @default.
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- W1941175183 date "1998-04-01" @default.
- W1941175183 modified "2023-10-14" @default.
- W1941175183 title "Involvement of C-Abl Tyrosine Kinase in Lipopolysaccharide- Induced Macrophage Activation" @default.
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- W1941175183 doi "https://doi.org/10.4049/jimmunol.160.7.3330" @default.
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