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- W1941330342 abstract "Chronic administration of four drugs of dependence (ethanol, morphine, nicotine and phenobarbitone) enhances rat brain 5-hydroxytryptamine synthesis, whereas subsequent withdrawal causes an inhibition. These opposite effects are caused by correspondingly opposite changes in tryptophan availability to the brain brought about by altered hepatic catabolism of tryptophan by the action of liver tryptophan pyrrolase. The metabolism and disposition of an exogenously administered tryptophan load are also altered in similar fashions. The results are discussed briefly in relation to the role of liver tryptophan pyrrolase in depressive illness and the possible involvement of tryptophan and 5-hydroxytryptamine in drug dependence." @default.
- W1941330342 created "2016-06-24" @default.
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- W1941330342 date "1983-11-01" @default.
- W1941330342 modified "2023-09-24" @default.
- W1941330342 title "OPPOSITE EFFECTS OF CHRONIC ADMINISTRATION AND SUBSEQUENT WITHDRAWAL OF DRUGS OF DEPENDENCE ON THE METABOLISM AND DISPOSITION OF ENDOGENOUS AND EXOGENOUS TRYPTOPHAN IN THE RAT" @default.
- W1941330342 doi "https://doi.org/10.1093/oxfordjournals.alcalc.a044391" @default.
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