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- W1941492228 abstract "Sera from dogs with spontaneously occurring and experimentally produced canine distemper virus-associated demyelinating encephalitis were examined for antibodies to central nervous system myelin by the complement fixation and indirect immunofluorescent methods. Complement-fixing immunoglobulin M antibodies and non-complement-fixing immunoglobulin G antibodies were found in 97% of the spontaneous cases. In comparison, only 28% of control sera contained these antibodies; furthermore, mean antibody titers in the control groups were significantly lower ( P < 0.005) when compared to the distemper group. Complement-fixing antimyelin antibodies were also demonstrated in gnotobiotic dogs with experimentally induced distemper virus-associated demyelination. The antibody response could be correlated with clinicopathological features of the disease produced. Results of this study indicate that demyelination in canine distemper may proceed by immune mechanisms." @default.
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- W1941492228 date "1973-11-01" @default.
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- W1941492228 title "Myelin-Specific Autoantibodies Associated with Central Nervous System Demyelination in Canine Distemper Virus Infection" @default.
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- W1941492228 doi "https://doi.org/10.1128/iai.8.5.819-827.1973" @default.
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