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- W1941509039 abstract "OBJECTIVE: To describe the clinical characteristics of a distinct form of exertional rhabdomyolysis, and compare this entity to exertional rhabdomyolysis attributable to metabolic myopathies. BACKGROUND: Rhabdomyolysis after exercise commonly alerts clinicians to the presence of a metabolic myopathy, such as McArdle disease or carnitine palmitoyltransferase 2 deficiency. However, rhabdomyolysis can occur in normal individuals after intense exercise, particularly with unaccustomed eccentric exercise. DESIGN/METHODS: We identified 4 patients who were referred to our institution for exertional rhabdomyolysis, who had no evidence of a metabolic defect with exercise, histological and biochemical testing. The clinical history in these patients was compared to patients referred with a history of exercise-induced rhabdomyolysis that proved to be secondary to metabolic myopathies, including patients with McArdle disease, carnitine palmitoyltransferase 2 deficiency, and phosphofructokinase deficiency. RESULTS: The timing between exercise and the onset of symptoms of muscle injury differed between the two groups. In metabolic myopathy patients, symptoms of muscle injury occurred immediately and myoglobinuria within hours of exercise. Commonly, these patients also had a life-long history of exercise intolerance. In contrast, patients with exertional rhabdomyolysis not associated with a metabolic myopathy, had minimal symptoms immediately after exercise and developed muscle pain, swelling, and myoglobinuria 12-36 hours after exercise which typically involved unaccustomed eccentric muscle contractions. These patients also had no history of prior exercise intolerance. CONCLUSIONS: Symptoms of muscle injury which develop 12-36 hours after exercise is not typical of metabolic myopathies, and instead suggests a distinctive form of exertional rhabdomyolysis attributable to a severe form of delayed onset muscle soreness. The diagnosis is suggested by preceding normal exercise tolerance, the involvement of eccentric muscle contractions, and by the typical latent period between exercise and muscle symptoms. Affected patients can generally be reassured of a low risk of recurrence. Disclosure: Dr. Haller has nothing to disclose." @default.
- W1941509039 created "2016-06-24" @default.
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- W1941509039 date "2014-04-08" @default.
- W1941509039 modified "2023-09-26" @default.
- W1941509039 title "A Distinctive, Delayed Form of Exertional Rhabdomyolysis (S36.005)" @default.
- W1941509039 hasPublicationYear "2014" @default.
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