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• W1941509619 startingPage "145" @default.
• W1941509619 abstract "Chromium is both a global marine pollutant and a known human health hazard. In this study, we compare the cytotoxicity and genotoxicity of both soluble and particulate chromate in human and hawksbill sea turtle (Eretmochelys imbricata) skin fibroblasts. Our data show that both soluble and particulate Cr(VI) induce concentration-dependent increases in cytotoxicity, genotoxicity, and intracellular Cr ion concentrations in both human and hawksbill sea turtle fibroblasts. Based on administered concentration, particulate and soluble Cr(VI) were more cytotoxic and clastogenic to human cells than sea turtle cells. When the analysis was based on the intracellular concentration of Cr, the data showed that the response of both species was similar. The one exception was the cytotoxicity of intracellular Cr ions from soluble Cr(VI), which caused more cytotoxicity in sea turtle cells (LC50 = 271 μM) than that of human cells (LC50 = 471 μM), but its clastogenicity was similar between the two species. Thus, adjusting for differences in uptake indicated that the explanation for the difference in potency was mostly due to uptake rather than differently affected mechanisms. Overall these data indicate that sea turtles may be a useful sentinel for human health responses to marine pollution." @default.
• W1941509619 created "2016-06-24" @default.
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• W1941509619 date "2015-12-01" @default.
• W1941509619 modified "2023-10-18" @default.
• W1941509619 title "Comparative cytotoxicity and genotoxicity of soluble and particulate hexavalent chromium in human and hawksbill sea turtle (Eretmochelys imbricata) skin cells" @default.
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• W1941509619 doi "https://doi.org/10.1016/j.cbpc.2015.09.013" @default.
• W1941509619 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4669981" @default.
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