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• W1941537992 abstract "Article1 September 1985free access Correlation between structure and pathogenicity of potato spindle tuber viroid (PSTV) Martina Schnölzer Martina Schnölzer Abteilung Viroidforschung, Max-Planck-Institut für Biochemie, D-8033 Martinsried, FRG Search for more papers by this author Bernd Haas Bernd Haas Abteilung Viroidforschung, Max-Planck-Institut für Biochemie, D-8033 Martinsried, FRG Search for more papers by this author Karla Ramm Karla Ramm Abteilung Viroidforschung, Max-Planck-Institut für Biochemie, D-8033 Martinsried, FRG Search for more papers by this author Hans Hofmann Hans Hofmann Rechenzentrum, Max-Planck-Institut für Biochemie, D-8033 Martinsried, FRG Search for more papers by this author Heinz L. Sänger Heinz L. Sänger Abteilung Viroidforschung, Max-Planck-Institut für Biochemie, D-8033 Martinsried, FRG Search for more papers by this author Martina Schnölzer Martina Schnölzer Abteilung Viroidforschung, Max-Planck-Institut für Biochemie, D-8033 Martinsried, FRG Search for more papers by this author Bernd Haas Bernd Haas Abteilung Viroidforschung, Max-Planck-Institut für Biochemie, D-8033 Martinsried, FRG Search for more papers by this author Karla Ramm Karla Ramm Abteilung Viroidforschung, Max-Planck-Institut für Biochemie, D-8033 Martinsried, FRG Search for more papers by this author Hans Hofmann Hans Hofmann Rechenzentrum, Max-Planck-Institut für Biochemie, D-8033 Martinsried, FRG Search for more papers by this author Heinz L. Sänger Heinz L. Sänger Abteilung Viroidforschung, Max-Planck-Institut für Biochemie, D-8033 Martinsried, FRG Search for more papers by this author Author Information Martina Schnölzer1, Bernd Haas1, Karla Ramm1, Hans Hofmann2 and Heinz L. Sänger1 1Abteilung Viroidforschung, Max-Planck-Institut für Biochemie, D-8033 Martinsried, FRG 2Rechenzentrum, Max-Planck-Institut für Biochemie, D-8033 Martinsried, FRG The EMBO Journal (1985)4:2181-2190https://doi.org/10.1002/j.1460-2075.1985.tb03913.x PDFDownload PDF of article text and main figures. ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinked InMendeleyWechatReddit Figures & Info Sequence analysis by primer-extension at the level of their cDNA showed that the RNA genomes of various field isolates of potato spindle tuber viroid (PSTV) of different virulence differ from each other only in a few nucleotides in two distinct regions of the rod-shaped molecule. Despite insertions and deletions the chain length of 359 nucleotides is strictly conserved in all the isolates studied. Thermodynamic calculations revealed that due to the observed sequence differences the region located at the left hand part of the rod-like secondary structure of the PSTV molecule, denoted ‘virulence modulating (VM) region’, becomes increasingly unstable with the increasing virulence of the corresponding isolate. Based on these data we propose in molecular terms a model for the mechanism of viroid pathogenicity. It implies that the nucleotides of the VM region specify and modulate the binding- and hence the competition-potential of the PSTV RNA molecule for a still unknown host factor(s) and thus determine the virulence of PSTV. Previous ArticleNext Article Volume 4Issue 91 September 1985In this issue RelatedDetailsLoading ..." @default.
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• W1941537992 date "1985-09-01" @default.
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• W1941537992 title "Correlation between structure and pathogenicity of potato spindle tuber viroid (PSTV)" @default.
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• W1941537992 doi "https://doi.org/10.1002/j.1460-2075.1985.tb03913.x" @default.
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