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- W1941558915 abstract "Biomarkers may be useful when deciding which nonsmall cell lung cancer (NSCLC) patients may benefit from adjuvant chemotherapy following complete resection and which chemotherapeutic agents may be used preferably in individual patients in order to maximise survival. A literature search covering the period from 2003 to May, 2014 was conducted using PubMed and the following search terms: non-small cell lung cancer, NSCLC, adjuvant chemotherapy, randomized, randomised, biomarkers, prognostic, predictive. This review focuses on current knowledge of biomarkers for prognosis or efficacy of adjuvant treatment following complete resection in stage I-IIIA NSCLC patients. This review includes results on 18 different biomarkers and five gene profiles. A statistically significant prognostic impact was reported for: iNTR, TUBB3, RRM1, ERCC1, BRCA1, p53, MRP2, MSH2, TS, mucin, BAG-1, pERK1/2, pAkt-1, microRNA, TopIIA, 15-gene profile, 92-gene profile, 31-gene profile and 14-gene profile. A statistically significant predictive impact was reported for: ERCC1, p53, MSH2, p27, TUBB3, PARP1, ATM, 37-gene profile, 31-gene profile, 15-gene profile and 92-gene profile. Uncertainties regarding the optimal analysis method and cut-off levels for the individual markers may blur the prognostic or predictive signals. None of the possible predictive markers have been validated in prospective trials. Thus, there are no biomarkers ready to use in an adjuvant setting in NSCLC." @default.
- W1941558915 created "2016-06-24" @default.
- W1941558915 creator A5052971613 @default.
- W1941558915 creator A5079045120 @default.
- W1941558915 date "2015-05-31" @default.
- W1941558915 modified "2023-10-17" @default.
- W1941558915 title "Biomarkers for efficacy of adjuvant chemotherapy following complete resection in NSCLC stages I–IIIA" @default.
- W1941558915 cites W1511967417 @default.
- W1941558915 cites W1512799850 @default.
- W1941558915 cites W1517655803 @default.
- W1941558915 cites W1839474261 @default.
- W1941558915 cites W1963581476 @default.
- W1941558915 cites W1964821477 @default.
- W1941558915 cites W1966463717 @default.
- W1941558915 cites W1971745560 @default.
- W1941558915 cites W1973179542 @default.
- W1941558915 cites W1979538859 @default.
- W1941558915 cites W1989123634 @default.
- W1941558915 cites W1989169445 @default.
- W1941558915 cites W1991596030 @default.
- W1941558915 cites W1993209405 @default.
- W1941558915 cites W1993371442 @default.
- W1941558915 cites W1994060622 @default.
- W1941558915 cites W1995923502 @default.
- W1941558915 cites W1996413533 @default.
- W1941558915 cites W2003268223 @default.
- W1941558915 cites W2004718750 @default.
- W1941558915 cites W2005599761 @default.
- W1941558915 cites W2010624323 @default.
- W1941558915 cites W2017103032 @default.
- W1941558915 cites W2017300261 @default.
- W1941558915 cites W2020612457 @default.
- W1941558915 cites W2021027398 @default.
- W1941558915 cites W2023365754 @default.
- W1941558915 cites W2027942886 @default.
- W1941558915 cites W2030751851 @default.
- W1941558915 cites W2036858259 @default.
- W1941558915 cites W2040935952 @default.
- W1941558915 cites W2045343940 @default.
- W1941558915 cites W2050249255 @default.
- W1941558915 cites W2050258759 @default.
- W1941558915 cites W2060139557 @default.
- W1941558915 cites W2070890790 @default.
- W1941558915 cites W2075549113 @default.
- W1941558915 cites W2083627679 @default.
- W1941558915 cites W2088720324 @default.
- W1941558915 cites W2096198395 @default.
- W1941558915 cites W2096834286 @default.
- W1941558915 cites W2096910745 @default.
- W1941558915 cites W2102252487 @default.
- W1941558915 cites W2103028520 @default.
- W1941558915 cites W2104504726 @default.
- W1941558915 cites W2111662961 @default.
- W1941558915 cites W2111665212 @default.
- W1941558915 cites W2114855342 @default.
- W1941558915 cites W2115157373 @default.
- W1941558915 cites W2119165414 @default.
- W1941558915 cites W2119424848 @default.
- W1941558915 cites W2119805434 @default.
- W1941558915 cites W2121110745 @default.
- W1941558915 cites W2124189886 @default.
- W1941558915 cites W2129360604 @default.
- W1941558915 cites W2133712354 @default.
- W1941558915 cites W2137737798 @default.
- W1941558915 cites W2147676721 @default.
- W1941558915 cites W2151620241 @default.
- W1941558915 cites W2151625463 @default.
- W1941558915 cites W2158086631 @default.
- W1941558915 cites W2158234609 @default.
- W1941558915 cites W2158734599 @default.
- W1941558915 cites W2161269127 @default.
- W1941558915 cites W2167278653 @default.
- W1941558915 cites W2169852451 @default.
- W1941558915 cites W2171381573 @default.
- W1941558915 cites W2250103185 @default.
- W1941558915 cites W2332574076 @default.
- W1941558915 cites W2526148797 @default.
- W1941558915 cites W2566863750 @default.
- W1941558915 cites W2596364503 @default.
- W1941558915 cites W2599403941 @default.
- W1941558915 cites W2806575069 @default.
- W1941558915 cites W4239714259 @default.
- W1941558915 cites W4297939389 @default.
- W1941558915 doi "https://doi.org/10.1183/16000617.00005814" @default.
- W1941558915 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26028645" @default.
- W1941558915 hasPublicationYear "2015" @default.
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