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• W1941737312 abstract "Newly formed glutamatergic synapses often lack postsynaptic AMPA-type glutamate receptors (AMPARs). Aside from 'unsilencing' the postsynaptic site, however, the significance of postsynaptic AMPAR insertion during synapse maturation remains unclear. To investigate the role of AMPAR in synapse maturation, we used RNA interference (RNAi) to knockdown AMPARs in cultured hippocampal neurons. Surprisingly, loss of postsynaptic AMPARs increased the occurrence of presynaptically inactive synapses without changing the release probability of the remaining active synapses. Additionally, heterologous synapses formed between axons and AMPAR-expressing HEK cells develop significantly fewer inactive presynaptic terminals. The extracellular domain of the AMPAR subunit GluA2 was sufficient to reproduce this effect at heterologous synapses. Indeed, the retrograde signalling by AMPARs is independent of their channel function as RNAi-resistant AMPARs restore synaptic transmission in neurons lacking AMPARs despite chronic receptor antagonist treatment. Our findings suggest that postsynaptic AMPARs perform an organizational function at synapses that exceeds their standard role as ionotropic receptors by conveying a retrograde trans-synaptic signal that increases the transmission efficacy at a synapse." @default.
• W1941737312 created "2016-06-24" @default.
• W1941737312 creator A5021896108 @default.
• W1941737312 creator A5037917072 @default.
• W1941737312 creator A5074204056 @default.
• W1941737312 date "2011-03-04" @default.
• W1941737312 modified "2023-10-14" @default.
• W1941737312 title "Acute knockdown of AMPA receptors reveals a trans-synaptic signal for presynaptic maturation" @default.
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• W1941737312 cites W1521104469 @default.
• W1941737312 cites W1571034236 @default.
• W1941737312 cites W1618714882 @default.
• W1941737312 cites W1690684669 @default.
• W1941737312 cites W1845163922 @default.
• W1941737312 cites W1964189494 @default.
• W1941737312 cites W1967804600 @default.
• W1941737312 cites W1972529694 @default.
• W1941737312 cites W1975086853 @default.
• W1941737312 cites W1978050645 @default.
• W1941737312 cites W1978779623 @default.
• W1941737312 cites W1989938166 @default.
• W1941737312 cites W1992603916 @default.
• W1941737312 cites W1993394859 @default.
• W1941737312 cites W1993536619 @default.
• W1941737312 cites W1993643645 @default.
• W1941737312 cites W1995680954 @default.
• W1941737312 cites W1996314349 @default.
• W1941737312 cites W1999772445 @default.
• W1941737312 cites W2000269403 @default.
• W1941737312 cites W2005577070 @default.
• W1941737312 cites W2013669507 @default.
• W1941737312 cites W2013720241 @default.
• W1941737312 cites W2016593669 @default.
• W1941737312 cites W2016812630 @default.
• W1941737312 cites W2019016101 @default.
• W1941737312 cites W2024301757 @default.
• W1941737312 cites W2025011598 @default.
• W1941737312 cites W2026351583 @default.
• W1941737312 cites W2028847552 @default.
• W1941737312 cites W2033907545 @default.
• W1941737312 cites W2036231188 @default.
• W1941737312 cites W2040673296 @default.
• W1941737312 cites W2045597434 @default.
• W1941737312 cites W2046165746 @default.
• W1941737312 cites W2050819309 @default.
• W1941737312 cites W2051378734 @default.
• W1941737312 cites W2051434331 @default.
• W1941737312 cites W2053794249 @default.
• W1941737312 cites W2055374196 @default.
• W1941737312 cites W2055720472 @default.
• W1941737312 cites W2056366478 @default.
• W1941737312 cites W2056429179 @default.
• W1941737312 cites W2056607057 @default.
• W1941737312 cites W2057605801 @default.
• W1941737312 cites W2058712930 @default.
• W1941737312 cites W2060202251 @default.
• W1941737312 cites W2064226680 @default.
• W1941737312 cites W2067100363 @default.
• W1941737312 cites W2067814945 @default.
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• W1941737312 cites W2097738233 @default.
• W1941737312 cites W2098434647 @default.
• W1941737312 cites W2098744542 @default.
• W1941737312 cites W2104310645 @default.
• W1941737312 cites W2106414999 @default.
• W1941737312 cites W2112927743 @default.
• W1941737312 cites W2113287822 @default.
• W1941737312 cites W2115316299 @default.
• W1941737312 cites W2120683418 @default.
• W1941737312 cites W2123355036 @default.
• W1941737312 cites W2126656642 @default.
• W1941737312 cites W2129082371 @default.
• W1941737312 cites W2129766810 @default.
• W1941737312 cites W2130784302 @default.
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• W1941737312 cites W2145731647 @default.
• W1941737312 cites W2147152912 @default.
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• W1941737312 doi "https://doi.org/10.1038/emboj.2011.59" @default.
• W1941737312 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3102285" @default.
• W1941737312 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21378752" @default.
• W1941737312 hasPublicationYear "2011" @default.
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