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- W194191331 abstract "This chapter explores the structural responses of a massive, hetero-oligomeric protein complex to a single allosteric activator as probed by a wide range of chemical, biochemical, and biophysical approaches. Some of the approaches used are amenable only to large protein targets, whereas others push the limits of their utility. Some of the techniques focus on individual subunits, or portions thereof, while others examine the complex as a whole. Despite the absence of crystallographic data for the complex, the diverse techniques identify and implicate a small region of its catalytic subunit as the master allosteric activation switch for the entire complex." @default.
- W194191331 created "2016-06-24" @default.
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- W194191331 date "2011-09-18" @default.
- W194191331 modified "2023-10-17" @default.
- W194191331 title "A Review of Methods Used for Identifying Structural Changes in a Large Protein Complex" @default.
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- W194191331 doi "https://doi.org/10.1007/978-1-61779-334-9_7" @default.
- W194191331 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3674763" @default.
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