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- W194215380 abstract "Acute leukemias are thought to arise from a single abnormal progenitor cell in which expression of differentiation is restricted to either myeloid or lymphoid pathways [1]. Recently, however, this concept has been challenged by the fact that the availability of monoclonal antibodies (moAbs) to lineage-associated surface antigens and their use to characterize immature leukemic cells demonstrate an increasing amount of multilineage differentiation and phenotypic ambiguity (reviewed in [2]). Furthermore, application of molecular biological techniques has revealed that clonal rearrangements of the Ig heavy-chain (IgH) or T-cell receptor (TCR) genes occur in leukemic cells of the “inappropriate” lineage (reviewed in [3])." @default.
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- W194215380 date "1990-01-01" @default.
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- W194215380 title "Incidence and Clinical Implications of Acute Hybrid Leukemia in Childhood" @default.
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- W194215380 doi "https://doi.org/10.1007/978-3-642-74643-7_93" @default.
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