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• W1942194807 abstract "The contribution of T cells to the host response to dengue virus (DENV) infection is not well understood. We previously demonstrated a protective role for CD8(+) T cells during primary DENV infection using a mouse-passaged DENV strain and IFN-α/βR(-/-) C57BL/6 mice, which are susceptible to DENV infection. In this study, we examine the role of CD4(+) T cells during primary DENV infection. Four I-A(b)-restricted epitopes derived from three of the nonstructural DENV proteins were identified. CD4(+) T cells expanded and were activated after DENV infection, with peak activation occurring on day 7. The DENV-specific CD4(+) T cells expressed intracellular IFN-γ, TNF, IL-2, and CD40L, and killed peptide-pulsed target cells in vivo. Surprisingly, depletion of CD4(+) T cells before DENV infection had no effect on viral loads. Consistent with this observation, CD4(+) T cell depletion did not affect the DENV-specific IgG or IgM Ab titers or their neutralizing activity, or the DENV-specific CD8(+) T cell response. However, immunization with the CD4(+) T cell epitopes before infection resulted in significantly lower viral loads. Thus, we conclude that whereas CD4(+) T cells are not required for controlling primary DENV infection, their induction by immunization can contribute to viral clearance. These findings suggest inducing anti-DENV CD4(+) T cell responses by vaccination may be beneficial." @default.
• W1942194807 created "2016-06-24" @default.
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• W1942194807 date "2010-09-24" @default.
• W1942194807 modified "2023-10-16" @default.
• W1942194807 title "CD4⁺T Cells Are Not Required for the Induction of Dengue Virus-Specific CD8⁺T Cell or Antibody Responses but Contribute to Protection after Vaccination" @default.
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• W1942194807 doi "https://doi.org/10.4049/jimmunol.1001709" @default.
• W1942194807 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2962919" @default.
• W1942194807 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20870934" @default.
• W1942194807 hasPublicationYear "2010" @default.
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