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• W1942237995 abstract "Zinc is the most abundant transition metal in the mammalian oocyte, and dynamic fluxes in intracellular concentration are essential for regulating both meiotic progression and fertilization. Whether the defined pathways of zinc utilization in female meiosis directly translate to mitotic cells, including the mammalian preimplantation embryo, has not been studied previously.We determined that zinc is the most abundant transition metal in the preimplantation embryo, with levels an order of magnitude higher than those of iron or copper. Using a zinc-specific fluorescent probe, we demonstrated that labile zinc is distributed in vesicle-like structures in the cortex of cells at all stages of preimplantation embryo development. To test the importance of zinc during this period, we induced zinc insufficiency using the heavy metal chelator N,N,N',N'-tetrakis-(2-pyridylmethyl)-ethylenediamine (TPEN). Incubation of embryos in media containing TPEN resulted in a developmental arrest that was specific to zinc chelation and associated with compromised mitotic parameters. The developmental arrest due to zinc insufficiency was associated with altered chromatin structure in the blastomere nuclei and decreased global transcription.These results demonstrate for the first time that the preimplantation embryo requires tight zinc regulation and homeostasis for the initial mitotic divisions of life." @default.
• W1942237995 created "2016-06-24" @default.
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• W1942237995 date "2015-07-16" @default.
• W1942237995 modified "2023-10-12" @default.
• W1942237995 title "The inorganic anatomy of the mammalian preimplantation embryo and the requirement of zinc during the first mitotic divisions" @default.
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• W1942237995 doi "https://doi.org/10.1002/dvdy.24285" @default.
• W1942237995 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4617753" @default.
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• W1942237995 hasPublicationYear "2015" @default.
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