Matches in SemOpenAlex for { <https://semopenalex.org/work/W1942249667> ?p ?o ?g. }
Showing items 1 to 92 of
92
with 100 items per page.
- W1942249667 endingPage "17" @default.
- W1942249667 startingPage "12" @default.
- W1942249667 abstract "Pharmacokinetic (PK) and pharmacodynamic (PD) principles that predict antimicrobial efficacy can be used to set targets for antimicrobial design and optimisation. Although current formulations of amoxicillin and amoxicillin/clavulanate have retained their efficacy against many, but not all, penicillin-nonsusceptible Streptococcus pneumoniae, additional coverage is required to address the growing problem of drug-resistant strains. Accordingly, two new oral formulations of amoxicillin/clavulanate, a paediatric formulation at 90/6.4 mg/kg/day and a pharmacokinetically enhanced formulation at 2000/125 mg twice daily for adults, were designed using PK/PD principles. These principles indicate that for amoxicillin and amoxicillin/clavulanate, a time above MIC of 35-40% of the dosing interval is predictive of high bacterial efficacy. In line with PK/PD predictions, simulation of human pharmacokinetics in in-vitro kinetic models and in a rat model of pneumonia, amoxicillin/clavulanate 2000/125 mg twice daily was highly effective against S. pneumoniae strains with amoxicillin MICs of 4 or 8 mg/L. Against strains with amoxicillin MICs of 4 mg/L, amoxicillin/clavulanate 2000/125 mg twice daily was significantly more effective than the conventional 875/125 mg twice daily formulation, azithromycin and levofloxacin, even though all levofloxacin MICs were < or = 1 mg/L. Following infection with S. pneumoniae strains with amoxicillin MICs of 8 mg/L, the amoxicillin/clavulanate 2000/125 mg twice daily formulation was more effective than the conventional amoxicillin/clavulanate formulations of 875/125 mg twice daily and three times daily and 1000/125 mg three times daily, and had similar or better efficacy than azithromycin and levofloxacin, depending on the strain. These data indicate the potential benefit of therapy with amoxicillin/clavulanate 2000/125 mg twice daily compared with conventional formulations and other marketed antimicrobials in the treatment of respiratory tract infection." @default.
- W1942249667 created "2016-06-24" @default.
- W1942249667 creator A5032227480 @default.
- W1942249667 date "2004-01-01" @default.
- W1942249667 modified "2023-10-16" @default.
- W1942249667 title "Proof of concept: performance testing in models" @default.
- W1942249667 cites W1983076976 @default.
- W1942249667 cites W2015720649 @default.
- W1942249667 cites W2017951949 @default.
- W1942249667 cites W2044932751 @default.
- W1942249667 cites W2046740395 @default.
- W1942249667 cites W2062495428 @default.
- W1942249667 cites W2067034394 @default.
- W1942249667 cites W2108655635 @default.
- W1942249667 cites W2111958253 @default.
- W1942249667 cites W2113717321 @default.
- W1942249667 cites W2117587576 @default.
- W1942249667 cites W2118792990 @default.
- W1942249667 cites W2119658374 @default.
- W1942249667 cites W2119660110 @default.
- W1942249667 cites W2122588250 @default.
- W1942249667 cites W2144126572 @default.
- W1942249667 cites W2147264575 @default.
- W1942249667 cites W2162398839 @default.
- W1942249667 cites W2166840599 @default.
- W1942249667 cites W2168840524 @default.
- W1942249667 cites W90489664 @default.
- W1942249667 doi "https://doi.org/10.1111/j.1470-9465.2004.00865.x" @default.
- W1942249667 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14759229" @default.
- W1942249667 hasPublicationYear "2004" @default.
- W1942249667 type Work @default.
- W1942249667 sameAs 1942249667 @default.
- W1942249667 citedByCount "19" @default.
- W1942249667 countsByYear W19422496672012 @default.
- W1942249667 countsByYear W19422496672013 @default.
- W1942249667 countsByYear W19422496672014 @default.
- W1942249667 countsByYear W19422496672015 @default.
- W1942249667 countsByYear W19422496672017 @default.
- W1942249667 countsByYear W19422496672018 @default.
- W1942249667 countsByYear W19422496672019 @default.
- W1942249667 crossrefType "journal-article" @default.
- W1942249667 hasAuthorship W1942249667A5032227480 @default.
- W1942249667 hasBestOaLocation W19422496671 @default.
- W1942249667 hasConcept C111113717 @default.
- W1942249667 hasConcept C112705442 @default.
- W1942249667 hasConcept C174802600 @default.
- W1942249667 hasConcept C2777288759 @default.
- W1942249667 hasConcept C2779454058 @default.
- W1942249667 hasConcept C2779708577 @default.
- W1942249667 hasConcept C2781253189 @default.
- W1942249667 hasConcept C2781276175 @default.
- W1942249667 hasConcept C3019249092 @default.
- W1942249667 hasConcept C501593827 @default.
- W1942249667 hasConcept C71924100 @default.
- W1942249667 hasConcept C86803240 @default.
- W1942249667 hasConcept C89423630 @default.
- W1942249667 hasConcept C98274493 @default.
- W1942249667 hasConceptScore W1942249667C111113717 @default.
- W1942249667 hasConceptScore W1942249667C112705442 @default.
- W1942249667 hasConceptScore W1942249667C174802600 @default.
- W1942249667 hasConceptScore W1942249667C2777288759 @default.
- W1942249667 hasConceptScore W1942249667C2779454058 @default.
- W1942249667 hasConceptScore W1942249667C2779708577 @default.
- W1942249667 hasConceptScore W1942249667C2781253189 @default.
- W1942249667 hasConceptScore W1942249667C2781276175 @default.
- W1942249667 hasConceptScore W1942249667C3019249092 @default.
- W1942249667 hasConceptScore W1942249667C501593827 @default.
- W1942249667 hasConceptScore W1942249667C71924100 @default.
- W1942249667 hasConceptScore W1942249667C86803240 @default.
- W1942249667 hasConceptScore W1942249667C89423630 @default.
- W1942249667 hasConceptScore W1942249667C98274493 @default.
- W1942249667 hasLocation W19422496671 @default.
- W1942249667 hasLocation W19422496672 @default.
- W1942249667 hasOpenAccess W1942249667 @default.
- W1942249667 hasPrimaryLocation W19422496671 @default.
- W1942249667 hasRelatedWork W1972321258 @default.
- W1942249667 hasRelatedWork W2009559080 @default.
- W1942249667 hasRelatedWork W2009705051 @default.
- W1942249667 hasRelatedWork W2068407850 @default.
- W1942249667 hasRelatedWork W2085805830 @default.
- W1942249667 hasRelatedWork W2100856600 @default.
- W1942249667 hasRelatedWork W2113491104 @default.
- W1942249667 hasRelatedWork W2166194120 @default.
- W1942249667 hasRelatedWork W2414899349 @default.
- W1942249667 hasRelatedWork W3021369409 @default.
- W1942249667 hasVolume "10" @default.
- W1942249667 isParatext "false" @default.
- W1942249667 isRetracted "false" @default.
- W1942249667 magId "1942249667" @default.
- W1942249667 workType "article" @default.