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- W194242562 abstract "Transforming growth factor-β(TGF-β) regulates cell growth inhibition, and perturbations of TGF-β signaling contribute to tumor progression. The effects of TGF-β growth inhibition are mediated by TGF-β receptors and Smad proteins. The role of TGF-β signaling in esophageal cancer has recently been elucidated. Although mutation of these genes is rare in esophageal cancer, alteration of the expression of these mediators correlates with tumor progression and poor prognosis. The mechanisms of the expression of the TGF-β signaling. mediators appear to be regulated by ubiquitin-dependent degradation. Consequently, transmission of TGF-β signaling may be hampered in esophageal cancer and loss of the growth inhibitory responses to TGF-β may occur in this disease. In summary, modulation of the expression of TGF-β singaling mediators is involved in the progression of esophageal cancer." @default.
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- W194242562 date "2008-01-01" @default.
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- W194242562 title "TGF-β and Progression of Esophageal Cancer" @default.
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- W194242562 doi "https://doi.org/10.1007/978-1-59745-293-9_9" @default.
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