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- W1942436673 abstract "Genomic medicine requires the identification of biomarkers and therapeutic targets, which in turn, requires high-quality biospecimens. Achieving high-quality biospecimens requires implementing standard operating procedures to control the variations of preanalytic variables in biobanking. Currently, most biobanks do not control the variations of preanalytic variables when collecting, processing, and storing their biospecimens. However, those variations have been shown to affect the quality of biospecimens and gene expression profiling.To identify evidence-based preanalytic parameters that can be applied and those parameters that need further study.We searched the Biospecimen Research and PubMed databases using defined key words. We retrieved and reviewed 212 articles obtained through those searches. We included 58 articles (27%) according to our inclusion and exclusion criteria for this review.-Preanalytic variables in biobanking can degrade the quality of biospecimens and alter gene expression profiling. Variables that require further study include the effect of surgical manipulation; the effect of warm ischemia; the allowable duration of delayed specimen processing; the optimal type, duration, and temperature of preservation and fixation; and the optimal storage duration of formalin-fixed, paraffin embedded specimens in a fit-for-purpose approach." @default.
- W1942436673 created "2016-06-24" @default.
- W1942436673 creator A5041098535 @default.
- W1942436673 creator A5063881405 @default.
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- W1942436673 date "2015-06-01" @default.
- W1942436673 modified "2023-10-04" @default.
- W1942436673 title "Biobanking in Genomic Medicine" @default.
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- W1942436673 doi "https://doi.org/10.5858/arpa.2014-0261-ra" @default.
- W1942436673 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4852858" @default.
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