Matches in SemOpenAlex for { <https://semopenalex.org/work/W1942817811> ?p ?o ?g. }
Showing items 1 to 80 of
80
with 100 items per page.
- W1942817811 endingPage "59" @default.
- W1942817811 startingPage "349" @default.
- W1942817811 abstract "[3H]Ethylketocyclazocine, in the presence of mu, delta and kappa-1 blocking agents, labels a high-affinity, saturable binding site in rat brain which we previously concluded might be the beta-endorphin-selective epsilon opioid receptor. However, studies failing to establish clearly the existence of the site in species other than rat raised the possibility that it might be an artifact or a unique constituent of rat tissues. Neither appears to be the case. We report here that, like other types of receptors, the site is proteinaceous with a sulfhydryl group within the binding site itself. Furthermore, the site appears to exist in two interchangeable, GTP-gamma-S-sensitive states which are readily distinguished by beta-endorphin, but not (-)-[3H]ethylketocyclazocine, and which are likely to be the site coupled to and uncoupled from a G protein. The putative epsilon receptor is not a peculiarity of rat brain but is readily measurable in forebrain of guinea pig, cow, chicken and pig brain as well. In fact, in all of the species examined, it is more abundant than mu, delta or kappa-1 receptors, representing 38 to 55% of the total opioid receptor population. The binding selectivity profile for drugs and the structure-activity relationship for beta-endorphin analogs indicated that the pharmacological properties of the putative epsilon receptor in brain are remarkably correlated with those of the epsilon receptor that was first hypothesized to exist in rat vas deferens and of the epsilon receptor that has been hypothesized to mediate the supraspinal analgesic effects of beta-endorphin." @default.
- W1942817811 created "2016-06-24" @default.
- W1942817811 creator A5009055582 @default.
- W1942817811 creator A5037324967 @default.
- W1942817811 creator A5058995389 @default.
- W1942817811 creator A5066118397 @default.
- W1942817811 date "1993-01-01" @default.
- W1942817811 modified "2023-09-26" @default.
- W1942817811 title "Properties of the putative epsilon opioid receptor: identification in rat, guinea pig, cow, pig and chicken brain." @default.
- W1942817811 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8380865" @default.
- W1942817811 hasPublicationYear "1993" @default.
- W1942817811 type Work @default.
- W1942817811 sameAs 1942817811 @default.
- W1942817811 citedByCount "17" @default.
- W1942817811 countsByYear W19428178112013 @default.
- W1942817811 countsByYear W19428178112022 @default.
- W1942817811 crossrefType "journal-article" @default.
- W1942817811 hasAuthorship W1942817811A5009055582 @default.
- W1942817811 hasAuthorship W1942817811A5037324967 @default.
- W1942817811 hasAuthorship W1942817811A5058995389 @default.
- W1942817811 hasAuthorship W1942817811A5066118397 @default.
- W1942817811 hasConcept C107824862 @default.
- W1942817811 hasConcept C126322002 @default.
- W1942817811 hasConcept C134018914 @default.
- W1942817811 hasConcept C141087196 @default.
- W1942817811 hasConcept C14397066 @default.
- W1942817811 hasConcept C170493617 @default.
- W1942817811 hasConcept C184389661 @default.
- W1942817811 hasConcept C185592680 @default.
- W1942817811 hasConcept C2778210472 @default.
- W1942817811 hasConcept C2778815084 @default.
- W1942817811 hasConcept C2779715522 @default.
- W1942817811 hasConcept C2779886867 @default.
- W1942817811 hasConcept C2781063702 @default.
- W1942817811 hasConcept C2908647359 @default.
- W1942817811 hasConcept C529278444 @default.
- W1942817811 hasConcept C55493867 @default.
- W1942817811 hasConcept C71924100 @default.
- W1942817811 hasConcept C86803240 @default.
- W1942817811 hasConcept C99454951 @default.
- W1942817811 hasConceptScore W1942817811C107824862 @default.
- W1942817811 hasConceptScore W1942817811C126322002 @default.
- W1942817811 hasConceptScore W1942817811C134018914 @default.
- W1942817811 hasConceptScore W1942817811C141087196 @default.
- W1942817811 hasConceptScore W1942817811C14397066 @default.
- W1942817811 hasConceptScore W1942817811C170493617 @default.
- W1942817811 hasConceptScore W1942817811C184389661 @default.
- W1942817811 hasConceptScore W1942817811C185592680 @default.
- W1942817811 hasConceptScore W1942817811C2778210472 @default.
- W1942817811 hasConceptScore W1942817811C2778815084 @default.
- W1942817811 hasConceptScore W1942817811C2779715522 @default.
- W1942817811 hasConceptScore W1942817811C2779886867 @default.
- W1942817811 hasConceptScore W1942817811C2781063702 @default.
- W1942817811 hasConceptScore W1942817811C2908647359 @default.
- W1942817811 hasConceptScore W1942817811C529278444 @default.
- W1942817811 hasConceptScore W1942817811C55493867 @default.
- W1942817811 hasConceptScore W1942817811C71924100 @default.
- W1942817811 hasConceptScore W1942817811C86803240 @default.
- W1942817811 hasConceptScore W1942817811C99454951 @default.
- W1942817811 hasIssue "1" @default.
- W1942817811 hasLocation W19428178111 @default.
- W1942817811 hasOpenAccess W1942817811 @default.
- W1942817811 hasPrimaryLocation W19428178111 @default.
- W1942817811 hasRelatedWork W1942817811 @default.
- W1942817811 hasRelatedWork W1982695711 @default.
- W1942817811 hasRelatedWork W2007930356 @default.
- W1942817811 hasRelatedWork W2012253169 @default.
- W1942817811 hasRelatedWork W2033927138 @default.
- W1942817811 hasRelatedWork W2085973610 @default.
- W1942817811 hasRelatedWork W2090630478 @default.
- W1942817811 hasRelatedWork W2090885361 @default.
- W1942817811 hasRelatedWork W95382183 @default.
- W1942817811 hasRelatedWork W961411076 @default.
- W1942817811 hasVolume "264" @default.
- W1942817811 isParatext "false" @default.
- W1942817811 isRetracted "false" @default.
- W1942817811 magId "1942817811" @default.
- W1942817811 workType "article" @default.