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- W1943081350 abstract "Objective: The purpose is to make clear the superiority of efficacy among the long-acting muscarinic antagonist (LAMA), super partial beta-2-agonist (super LABA) and the combination therapy on dynamic lung hyperinflation (DLH). Patients and Methods : 24 stable patients with mild to severe COPD were enrolled from our out-patient clinic and divided into the two groups at random following basement measurements after 48-hour washout current long-acting bronchodilator therapy. One group was treated with 5μg of tiotropium (Respimat inhaler) for 4 weeks following the 4 weeks-treatment with 150mg of indacaterol, while the other group was treated with indacaterol for 4 weeks following 4-weeks-treatment with tiotropium, and finally treated with the combination of the two drugs for 4 weeks. Pulmonary function tests including DLH evaluated by the method of metronome-paced incremental hyperventilation (MPIH) and exercise tolerance evaluated by shuttle walking test were examined at the end of the each treatment period. Results: Both the treatment with tiotropium and indacaterol alone significantly increased FEV 1 and the shuttle walking distance and improved COPD assessment test (CAT) score. However, tiotropium significantly improved the DLH following MPIH, but the treatment with indacaterol did not. The combination therapy resulted in further improvement of lung function and exercise tolerance. Conclusions: The mono-therapy of tiotropium or indacaterol improves airflow obstruction and exercise tolerance as well, and the combination therapy results in further improvement. However, the efficacy of tiotropium for DLH may be superior to indacaterol." @default.
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- W1943081350 date "2014-09-01" @default.
- W1943081350 modified "2023-09-26" @default.
- W1943081350 title "Efficacy of tiotropium and indacaterol alone or the combination on dynamic lung hyperinflation and exercise tolerance in COPD" @default.
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