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- W1943114611 endingPage "1263" @default.
- W1943114611 startingPage "1249" @default.
- W1943114611 abstract "Matrix metalloproteinases (MMPs) are extracellular proteolytic enzymes that contribute to pericellular remodeling in a variety of tissues, including brain, where they function in adult hippocampal synaptic structural and functional plasticity. Synaptic plasticity and remodeling are also important for development of connectivity, but it is unclear whether MMPs--particularly MMP-2 and -9, the major MMPs operative in brain--contribute at these stages. Here, we use a combination of biochemical and anatomical methods to characterize expression and localization of MMP-2 and MMP-9 in early postnatal and adult rat hippocampus. Gene and protein expression of these MMPs were evident throughout hippocampus at all ages examined, but expression levels were highest during the first postnatal week. MMP-2 and MMP-9 immunolocalized to punctate structures within the neuropil that codistributed with foci of proteolytic activity, as well as with markers of growing axons and synapses. Taken together, discrete foci of MMP proteolysis are likely important for actively shaping and remodeling cellular and connectional architecture as hippocampal circuitry is becoming established during early postnatal life." @default.
- W1943114611 created "2016-06-24" @default.
- W1943114611 creator A5005979256 @default.
- W1943114611 creator A5011151657 @default.
- W1943114611 date "2014-03-14" @default.
- W1943114611 modified "2023-10-16" @default.
- W1943114611 title "Early postnatal expression and localization of matrix metalloproteinases-2 and -9 during establishment of rat hippocampal synaptic circuitry" @default.
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- W1943114611 doi "https://doi.org/10.1002/cne.23468" @default.
- W1943114611 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4909053" @default.
- W1943114611 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24114974" @default.
- W1943114611 hasPublicationYear "2014" @default.
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