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- W1943150066 abstract "Centrosome cohesion and separation are regulated throughout the cell cycle, but the underlying mechanisms are not well understood. Since overexpression of a protein kinase, Nek2, is able to trigger centrosome splitting (the separation of parental centrioles), we have surveyed a panel of centrosome-associated kinases for their ability to induce a similar phenotype. Cdk2, in association with either cyclin A or E, was as effective as Nek2, but several other kinases tested did not significantly interfere with centrosome cohesion. Centrosome splitting could also be triggered by inhibition of phosphatases, and protein phosphatase 1α (PP1α) was identified as a likely physiological antagonist of Nek2. Furthermore, we have revisited the role of the microtubule network in the control of centrosome cohesion. We could confirm that microtubule depolymerization by nocodazole causes centrosome splitting. Surprisingly, however, this drug-induced splitting also required kinase activity and could specifically be suppressed by a dominant-negative mutant of Nek2. These studies highlight the importance of protein phosphorylation in the control of centrosome cohesion, and they point to Nek2 and PP1α as critical regulators of centrosome structure." @default.
- W1943150066 created "2016-06-24" @default.
- W1943150066 creator A5011169979 @default.
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- W1943150066 date "2001-10-15" @default.
- W1943150066 modified "2023-10-16" @default.
- W1943150066 title "Centrosome cohesion is regulated by a balance of kinase and phosphatase activities" @default.
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- W1943150066 doi "https://doi.org/10.1242/jcs.114.20.3749" @default.
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