FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1943173654> ?p ?o ?g. }

• W1943173654 endingPage "435" @default.
• W1943173654 startingPage "425" @default.
• W1943173654 abstract "Abstract Histone deacetylase (HDAC) inhibitors have attracted much interest because of their ability to arrest cell growth, induce cell differentiation, and in some cases, induce apoptosis of cancer cells. In the present study, we have examined a new HDAC inhibitor, suberic bishydroxamate (SBHA), for its effect on a panel of human melanoma cell lines. We report that it induces varying degrees of apoptosis in the melanoma lines but not in melanocytes and fibroblasts. Induction of apoptosis was caspase dependent and was associated with induction of changes in mitochondrial membrane permeability, which could be inhibited by overexpression of Bcl-2. The changes in mitochondria were independent of caspase activation and were associated with changes in conformation of Bax. SBHA down-regulated several key antiapoptotic proteins including X-linked inhibitor of apoptosis and the Bcl-2 family proteins, Bcl-XL and Mcl-1. In contrast, it induced up-regulation of the Bcl-2 family proapoptotic proteins, Bim, Bax, and Bak. In addition, SBHA induced relocation of the protein Bim to mitochondria and its association with Bcl-2. De novo protein synthesis was required for initiation of apoptosis in that the protein synthesis inhibitor, cycloheximide, inhibited SBHA-induced conformational changes in Bax as well as changes in mitochondrial membrane permeability and activation of caspase-3. These results suggest that SBHA induces apoptosis by changing the balance between proapoptotic and antiapoptotic proteins in melanoma cells. The protein Bim may be a key initiator of apoptosis in cells treated with SBHA." @default.
• W1943173654 created "2016-06-24" @default.
• W1943173654 creator A5041783298 @default.
• W1943173654 creator A5052994601 @default.
• W1943173654 creator A5055038393 @default.
• W1943173654 creator A5072813429 @default.
• W1943173654 date "2004-04-01" @default.
• W1943173654 modified "2023-10-16" @default.
• W1943173654 title "The histone deacetylase inhibitor suberic bishydroxamate regulates the expression of multiple apoptotic mediators and induces mitochondria-dependent apoptosis of melanoma cells" @default.
• W1943173654 cites W1511815964 @default.
• W1943173654 cites W1563624749 @default.
• W1943173654 cites W1866128922 @default.
• W1943173654 cites W1968867081 @default.
• W1943173654 cites W1974090542 @default.
• W1943173654 cites W1981166298 @default.
• W1943173654 cites W1990861922 @default.
• W1943173654 cites W1993059855 @default.
• W1943173654 cites W2000093730 @default.
• W1943173654 cites W2001101815 @default.
• W1943173654 cites W2005296854 @default.
• W1943173654 cites W2006978594 @default.
• W1943173654 cites W2008715871 @default.
• W1943173654 cites W2009616940 @default.
• W1943173654 cites W2011785467 @default.
• W1943173654 cites W2016330660 @default.
• W1943173654 cites W2021350221 @default.
• W1943173654 cites W2024996523 @default.
• W1943173654 cites W2052451504 @default.
• W1943173654 cites W2053420149 @default.
• W1943173654 cites W2053527426 @default.
• W1943173654 cites W2057727344 @default.
• W1943173654 cites W2070872482 @default.
• W1943173654 cites W2073028327 @default.
• W1943173654 cites W2076710136 @default.
• W1943173654 cites W2076836169 @default.
• W1943173654 cites W2079650395 @default.
• W1943173654 cites W2082739830 @default.
• W1943173654 cites W2107528191 @default.
• W1943173654 cites W2108197605 @default.
• W1943173654 cites W2114001234 @default.
• W1943173654 cites W2119546313 @default.
• W1943173654 cites W2132411546 @default.
• W1943173654 cites W2133792873 @default.
• W1943173654 cites W2140967934 @default.
• W1943173654 cites W2143658931 @default.
• W1943173654 cites W2152247516 @default.
• W1943173654 cites W2313663700 @default.
• W1943173654 cites W2321015982 @default.
• W1943173654 cites W69776591 @default.
• W1943173654 doi "https://doi.org/10.1158/1535-7163.425.3.4" @default.
• W1943173654 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15078986" @default.
• W1943173654 hasPublicationYear "2004" @default.
• W1943173654 type Work @default.
• W1943173654 sameAs 1943173654 @default.
• W1943173654 citedByCount "119" @default.
• W1943173654 countsByYear W19431736542012 @default.
• W1943173654 countsByYear W19431736542013 @default.
• W1943173654 countsByYear W19431736542014 @default.
• W1943173654 countsByYear W19431736542015 @default.
• W1943173654 countsByYear W19431736542016 @default.
• W1943173654 countsByYear W19431736542017 @default.
• W1943173654 countsByYear W19431736542018 @default.
• W1943173654 countsByYear W19431736542019 @default.
• W1943173654 countsByYear W19431736542020 @default.
• W1943173654 countsByYear W19431736542021 @default.
• W1943173654 countsByYear W19431736542022 @default.
• W1943173654 countsByYear W19431736542023 @default.
• W1943173654 crossrefType "journal-article" @default.
• W1943173654 hasAuthorship W1943173654A5041783298 @default.
• W1943173654 hasAuthorship W1943173654A5052994601 @default.
• W1943173654 hasAuthorship W1943173654A5055038393 @default.
• W1943173654 hasAuthorship W1943173654A5072813429 @default.
• W1943173654 hasBestOaLocation W19431736541 @default.
• W1943173654 hasConcept C104317684 @default.
• W1943173654 hasConcept C153911025 @default.
• W1943173654 hasConcept C170301204 @default.
• W1943173654 hasConcept C185592680 @default.
• W1943173654 hasConcept C190283241 @default.
• W1943173654 hasConcept C2776202225 @default.
• W1943173654 hasConcept C2778128677 @default.
• W1943173654 hasConcept C2778305200 @default.
• W1943173654 hasConcept C28859421 @default.
• W1943173654 hasConcept C31573885 @default.
• W1943173654 hasConcept C3675279 @default.
• W1943173654 hasConcept C502942594 @default.
• W1943173654 hasConcept C55493867 @default.
• W1943173654 hasConcept C64927066 @default.
• W1943173654 hasConcept C86803240 @default.
• W1943173654 hasConcept C95444343 @default.
• W1943173654 hasConcept C98424977 @default.
• W1943173654 hasConceptScore W1943173654C104317684 @default.
• W1943173654 hasConceptScore W1943173654C153911025 @default.
• W1943173654 hasConceptScore W1943173654C170301204 @default.
• W1943173654 hasConceptScore W1943173654C185592680 @default.
• W1943173654 hasConceptScore W1943173654C190283241 @default.
• W1943173654 hasConceptScore W1943173654C2776202225 @default.
• W1943173654 hasConceptScore W1943173654C2778128677 @default.
• W1943173654 hasConceptScore W1943173654C2778305200 @default.

• next