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- W1943293840 abstract "We examined the changes in isolated pulmonary artery (PA) wall tension on switching from control conditions (pH 7.38 ± 0.01,[Formula: see text] 32.9 ± 0.4 Torr) to isohydric hypercapnia (pH change 0.00 ± 0.01,[Formula: see text] change 24.9 ± 1.1 Torr) or normocapnic acidosis (pH change −0.28 ± 0.01,[Formula: see text] change −0.3 ± 0.04 Torr) and the role of the endothelium in these responses. In rat PA, submaximally contracted with phenylephrine, isohydric hypercapnia did not cause a significant change in mean (± SE) tension [3.0 ± 1.8% maximal phenylephrine-induced tension (P o )]. Endothelial removal did not alter this response. In aortic preparations, isohydric hypercapnia caused significant ( P < 0.01) relaxation (−27.4 ± 3.2% P o ), which was largely endothelium dependent. Normocapnic acidosis caused relaxation of PA (−20.2 ± 2.6% P o ), which was less ( P < 0.01) than that observed in aortic preparations (−35.7 ± 3.4% P o ). Endothelial removal left the pulmonary response unchanged while increasing ( P < 0.01) the aortic relaxation (−53.1 ± 4.4% P o ). These data show that isohydric hypercapnia does not alter PA tone. Reduction of PA tone in normocapnic acidosis is endothelium independent and substantially less than that of systemic vessels." @default.
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- W1943293840 date "1998-12-01" @default.
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- W1943293840 title "Effects of changes in pH and CO<sub>2</sub> on pulmonary arterial wall tension are not endothelium dependent" @default.
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- W1943293840 doi "https://doi.org/10.1152/jappl.1998.85.6.2040" @default.
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