Matches in SemOpenAlex for { <https://semopenalex.org/work/W1943961567> ?p ?o ?g. }
Showing items 1 to 73 of
73
with 100 items per page.
- W1943961567 endingPage "2982" @default.
- W1943961567 startingPage "2974" @default.
- W1943961567 abstract "Abstract Staphylococcal protein A (SPA) is known to bind preferentially to the VH3 family of Ig heavy chain variable gene products. The current studies were conducted to examine the functional capacity of SPA to induce Ig production by VH3-expressing human B cells preferentially. Human peripheral blood B cells stimulated with anti-CD3-activated T cells or the Wood 46 strain of Staphylococcus aureus, which lacks SPA, expressed IgM containing all VH families, as detected by reverse transcription-PCR. In contrast, stimulation with SPA containing S. aureus or SPA-Sepharose resulted in biased expression of VH3 containing IgM. Similarly, cord blood B cells that require costimulation for Ig production induced by anti-CD3-activated T cells produced only VH3 containing IgM on costimulation with SPA containing S. aureus. The sequences of 21 VH3 IgM gene products derived from different B cell sources were determined and found to include at least nine members of the VH3 family, which were both in germ-line configuration and somatically mutated. Use of DH and JH was diverse. Analysis of these VH3 gene products revealed conserved residues in FR1 and 3'CDR2/FR3, which are candidates to play a role in SPA-mediated activation of VH3-expressing B cells. Like T cell superantigens, SPA probably interacts with residues in the partially solvent exposed regions of the heavy chain molecule outside the classical Ag binding site and provides a signal that can lead to Ig production by human B cells expressing VH3." @default.
- W1943961567 created "2016-06-24" @default.
- W1943961567 creator A5001316008 @default.
- W1943961567 creator A5022856152 @default.
- W1943961567 creator A5043874873 @default.
- W1943961567 date "1994-10-01" @default.
- W1943961567 modified "2023-10-11" @default.
- W1943961567 title "Staphylococcal protein A induces biased production of Ig by VH3-expressing B lymphocytes." @default.
- W1943961567 doi "https://doi.org/10.4049/jimmunol.153.7.2974" @default.
- W1943961567 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8089481" @default.
- W1943961567 hasPublicationYear "1994" @default.
- W1943961567 type Work @default.
- W1943961567 sameAs 1943961567 @default.
- W1943961567 citedByCount "57" @default.
- W1943961567 countsByYear W19439615672012 @default.
- W1943961567 countsByYear W19439615672013 @default.
- W1943961567 countsByYear W19439615672014 @default.
- W1943961567 countsByYear W19439615672015 @default.
- W1943961567 countsByYear W19439615672016 @default.
- W1943961567 countsByYear W19439615672017 @default.
- W1943961567 countsByYear W19439615672018 @default.
- W1943961567 countsByYear W19439615672021 @default.
- W1943961567 countsByYear W19439615672022 @default.
- W1943961567 countsByYear W19439615672023 @default.
- W1943961567 crossrefType "journal-article" @default.
- W1943961567 hasAuthorship W1943961567A5001316008 @default.
- W1943961567 hasAuthorship W1943961567A5022856152 @default.
- W1943961567 hasAuthorship W1943961567A5043874873 @default.
- W1943961567 hasBestOaLocation W19439615671 @default.
- W1943961567 hasConcept C137756551 @default.
- W1943961567 hasConcept C153911025 @default.
- W1943961567 hasConcept C159654299 @default.
- W1943961567 hasConcept C185592680 @default.
- W1943961567 hasConcept C203014093 @default.
- W1943961567 hasConcept C2776090121 @default.
- W1943961567 hasConcept C2778453870 @default.
- W1943961567 hasConcept C2779000548 @default.
- W1943961567 hasConcept C36333154 @default.
- W1943961567 hasConcept C86803240 @default.
- W1943961567 hasConcept C8891405 @default.
- W1943961567 hasConceptScore W1943961567C137756551 @default.
- W1943961567 hasConceptScore W1943961567C153911025 @default.
- W1943961567 hasConceptScore W1943961567C159654299 @default.
- W1943961567 hasConceptScore W1943961567C185592680 @default.
- W1943961567 hasConceptScore W1943961567C203014093 @default.
- W1943961567 hasConceptScore W1943961567C2776090121 @default.
- W1943961567 hasConceptScore W1943961567C2778453870 @default.
- W1943961567 hasConceptScore W1943961567C2779000548 @default.
- W1943961567 hasConceptScore W1943961567C36333154 @default.
- W1943961567 hasConceptScore W1943961567C86803240 @default.
- W1943961567 hasConceptScore W1943961567C8891405 @default.
- W1943961567 hasIssue "7" @default.
- W1943961567 hasLocation W19439615671 @default.
- W1943961567 hasLocation W19439615672 @default.
- W1943961567 hasOpenAccess W1943961567 @default.
- W1943961567 hasPrimaryLocation W19439615671 @default.
- W1943961567 hasRelatedWork W1507725507 @default.
- W1943961567 hasRelatedWork W1658720549 @default.
- W1943961567 hasRelatedWork W1943961567 @default.
- W1943961567 hasRelatedWork W2005521699 @default.
- W1943961567 hasRelatedWork W2075634030 @default.
- W1943961567 hasRelatedWork W2117287173 @default.
- W1943961567 hasRelatedWork W2146603724 @default.
- W1943961567 hasRelatedWork W2474091620 @default.
- W1943961567 hasRelatedWork W3029908218 @default.
- W1943961567 hasRelatedWork W4313354683 @default.
- W1943961567 hasVolume "153" @default.
- W1943961567 isParatext "false" @default.
- W1943961567 isRetracted "false" @default.
- W1943961567 magId "1943961567" @default.
- W1943961567 workType "article" @default.