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- W1944101890 abstract "To radiolabel bioactive molecules, we synthesized Tc-tricarbonyl precursor, [Tc(CO)()] with a low oxidation state ( I ). The [Tc(CO)()] was prepared by low pressure carbonylation (1 atm of CO) of [Tc )] in the presence of NaB resulting in higher than 98% of labeling yield and stability up to 8 hrs. We evaluated the characteristics of Tc- tricarbonyl labeled bioactive molecules by carrying out in vitro and in vitro study. Prepared [Tc(CO)()] was then reacted with some ligands of significance in modem diagnostic nuclear medicine and some amino acids. Labeling yields were checked by HPLC and found to be usually high, excluding Tc-tricarbonyl-MDP, -EDTMP and -mIBG. And the biodistribution properties of Tc-tricarbonyl complexes applied in rabbit showed different appearance comparing with that of the Tc-labeling by conventional means. From these results, we conclude that [Tc(CO)()] is a potential precursor to. development ofecursor to. development off" @default.
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- W1944101890 date "2002-04-01" @default.
- W1944101890 modified "2023-09-27" @default.
- W1944101890 title "Synthesis of 99m Tc-tricarbonyl Prcursors for Labeling of Bioactive Molecules" @default.
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