FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1944138080> ?p ?o ?g. }

• W1944138080 endingPage "2053" @default.
• W1944138080 startingPage "2047" @default.
• W1944138080 abstract "The extracellular protein p60 is a major virulence factor of the intracellular bacterium Listeria monocytogenes. Its roles in pathogen survival in vivo and host cell invasion in vitro were studied. To this end, Salmonella typhimurium SL7207 was used as carrier for secreted p60-HlyA fusion protein by Escherichia coli HlyB and HlyD transport proteins. C57BL/6 mice infected intravenously with this strain suffered from increased bacterial numbers in livers and spleens compared with the p60-nonexpressing control strain, but only transiently. In vitro experiments showed that p60 promotes invasion of recombinant S. typhimurium SL7207 p60 into hepatocytes and resting macrophages independent from complement. Moreover, the uptake of wild-type L. monocytogenes EGD and L. monocytogenes BUG 8, an internalin-deficient strain, into hepatocytes was partially blocked by anti-p60 antibodies. The impaired invasion of dissociated bacterial chains of L. monocytogenes RIII, a p60 expression mutant, into hepatocytes and macrophages was partially restored by addition of p60- or p60-HlyA-enriched bacterial supernatants. These data suggest that the L. monocytogenes surface-associated proteins, p60 and internalin, act in concert to achieve optimal uptake into nonprofessional phagocytes and macrophages. Together, these experiments reveal a substantial impact of p60 on cell invasion and virulence and thus emphasize the importance of the intracellular habitat for survival of L. monocytogenes in the host." @default.
• W1944138080 created "2016-06-24" @default.
• W1944138080 creator A5025017281 @default.
• W1944138080 creator A5025189865 @default.
• W1944138080 creator A5030665080 @default.
• W1944138080 creator A5043503303 @default.
• W1944138080 creator A5046428914 @default.
• W1944138080 creator A5048861599 @default.
• W1944138080 creator A5063435247 @default.
• W1944138080 date "1995-05-01" @default.
• W1944138080 modified "2023-09-27" @default.
• W1944138080 title "Listeria monocytogenes p60 supports host cell invasion by and in vivo survival of attenuated Salmonella typhimurium" @default.
• W1944138080 cites W1492433545 @default.
• W1944138080 cites W1549135851 @default.
• W1944138080 cites W1660583778 @default.
• W1944138080 cites W1875181748 @default.
• W1944138080 cites W1879760903 @default.
• W1944138080 cites W1884351988 @default.
• W1944138080 cites W1903197063 @default.
• W1944138080 cites W1916262944 @default.
• W1944138080 cites W1923780681 @default.
• W1944138080 cites W1960902446 @default.
• W1944138080 cites W2002510848 @default.
• W1944138080 cites W2007400073 @default.
• W1944138080 cites W2015757689 @default.
• W1944138080 cites W2017526911 @default.
• W1944138080 cites W2024876177 @default.
• W1944138080 cites W2028247608 @default.
• W1944138080 cites W2036685307 @default.
• W1944138080 cites W2042048278 @default.
• W1944138080 cites W2050634031 @default.
• W1944138080 cites W2050849651 @default.
• W1944138080 cites W2053152876 @default.
• W1944138080 cites W2055268155 @default.
• W1944138080 cites W2055351624 @default.
• W1944138080 cites W2059164137 @default.
• W1944138080 cites W2065433133 @default.
• W1944138080 cites W2087448560 @default.
• W1944138080 cites W2088034275 @default.
• W1944138080 cites W2100837269 @default.
• W1944138080 cites W2101108802 @default.
• W1944138080 cites W2113539024 @default.
• W1944138080 cites W2119919523 @default.
• W1944138080 cites W2127557420 @default.
• W1944138080 cites W2131766451 @default.
• W1944138080 cites W2139522919 @default.
• W1944138080 cites W2139535814 @default.
• W1944138080 cites W2140028577 @default.
• W1944138080 cites W2141462914 @default.
• W1944138080 cites W2147920576 @default.
• W1944138080 cites W2154933996 @default.
• W1944138080 cites W2158252361 @default.
• W1944138080 cites W2989345970 @default.
• W1944138080 doi "https://doi.org/10.1128/iai.63.5.2047-2053.1995" @default.
• W1944138080 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/173263" @default.
• W1944138080 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7729919" @default.
• W1944138080 hasPublicationYear "1995" @default.
• W1944138080 type Work @default.
• W1944138080 sameAs 1944138080 @default.
• W1944138080 citedByCount "74" @default.
• W1944138080 countsByYear W19441380802012 @default.
• W1944138080 countsByYear W19441380802013 @default.
• W1944138080 countsByYear W19441380802014 @default.
• W1944138080 countsByYear W19441380802016 @default.
• W1944138080 countsByYear W19441380802019 @default.
• W1944138080 countsByYear W19441380802020 @default.
• W1944138080 countsByYear W19441380802022 @default.
• W1944138080 crossrefType "journal-article" @default.
• W1944138080 hasAuthorship W1944138080A5025017281 @default.
• W1944138080 hasAuthorship W1944138080A5025189865 @default.
• W1944138080 hasAuthorship W1944138080A5030665080 @default.
• W1944138080 hasAuthorship W1944138080A5043503303 @default.
• W1944138080 hasAuthorship W1944138080A5046428914 @default.
• W1944138080 hasAuthorship W1944138080A5048861599 @default.
• W1944138080 hasAuthorship W1944138080A5063435247 @default.
• W1944138080 hasBestOaLocation W19441380801 @default.
• W1944138080 hasConcept C104317684 @default.
• W1944138080 hasConcept C150903083 @default.
• W1944138080 hasConcept C153726182 @default.
• W1944138080 hasConcept C202751555 @default.
• W1944138080 hasConcept C207001950 @default.
• W1944138080 hasConcept C2776460866 @default.
• W1944138080 hasConcept C2778682378 @default.
• W1944138080 hasConcept C2778910516 @default.
• W1944138080 hasConcept C2781065037 @default.
• W1944138080 hasConcept C2781090273 @default.
• W1944138080 hasConcept C2781350384 @default.
• W1944138080 hasConcept C28406088 @default.
• W1944138080 hasConcept C523546767 @default.
• W1944138080 hasConcept C54355233 @default.
• W1944138080 hasConcept C547475151 @default.
• W1944138080 hasConcept C55493867 @default.
• W1944138080 hasConcept C60987743 @default.
• W1944138080 hasConcept C79879829 @default.
• W1944138080 hasConcept C86803240 @default.
• W1944138080 hasConcept C89423630 @default.
• W1944138080 hasConcept C95444343 @default.
• W1944138080 hasConceptScore W1944138080C104317684 @default.

• next