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• W19442906 abstract "The cumulated data indicate that in postmenopausal women <60 years old, ET significantly reduces total mortality and CHD. In addition, the risks of concern for ET such as stroke and breast cancer were not elevated in postmenopausal women <60 years old. VTE associated with ET is rare and no greater than other commonly used medications. The risks and benefits of ET compare favorably to aspirin and lipid-lowering therapy for the primary prevention of CHD.With the risks and benefits of ET in clinical perspective, the cumulated data indicate that ET is an effective therapy for the primary prevention of CHD if initiated in postmenopausal women <60 years old. The large and consistent body of observational and randomized controlled trial data indicate that in recently menopausal women, ET reduces total mortality and CHD. Surveying randomized controlled trial evidence indicates that ET has the strongest evidence for reducing both total mortality and CHD in postmenopausal women when initiated before age 60 (2-4).The evidence for a preventive role of ET in certain postmenopausal women is stronger than ever (2-4). WHI has not only confirmed the known benefits of ET from observational studies but has also shown the relative safety of ET under randomized controlled conditions in women under age 60. WHI confirms 40 years of consistent observational data that women who initiate ET in close proximity to menopause have a significant reduction in total mortality and CHD. In addition, WHI has shown that ET (CEE) reduces breast cancer risk similar to that of SERM agents (29) and the remaining risk, VTE associated with ET is rare (<1/1,000). In general, the risks in women less than 60 years old who initiate ET in close proximity to menopause are no greater than other medications used for the primary prevention of CHD in women (2).The Early versus Late Intervention Trial with Estradiol (ELITE) funded by the National Institute on Aging is designed to specifically address the ‘timing of initiation hypothesis’ (2-4) providing further insight into the effect of ET in young versus older postmenopausal women (30). Although the Kronos Early Estrogen Prevention Study (KEEPS), a privately funded trial does not have a comparative older group of women, it will provide insight into the effects of several HT regimens in young postmenopausal women.Until shown otherwise, women and health care providers can feel comfortable that the cumulated data including those from WHI indicate that ET, in particular CEE, is safe and effective in reducing total mortality and CHD in women who initiate ET in close proximity to menopause." @default.
• W19442906 created "2016-06-24" @default.
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• W19442906 date "2008-03-01" @default.
• W19442906 modified "2023-09-25" @default.
• W19442906 title "In Perspective: Estrogen Therapy Proves to Safely and Effectively Reduce Total Mortality and Coronary Heart Disease in Recently Postmenopausal Women." @default.
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