Matches in SemOpenAlex for { <https://semopenalex.org/work/W1944333546> ?p ?o ?g. }
- W1944333546 endingPage "1685" @default.
- W1944333546 startingPage "1673" @default.
- W1944333546 abstract "Pyoverdines, the main siderophores of fluorescent pseudomonads, contain a peptide moiety, different for each pyoverdine, and an identical chromophore. While it has been shown that non-ribosomal peptide synthetases (NRPSs) are involved in the biosynthesis of the peptide chain of pyoverdines, this was not demonstrated for the biosynthesis of the chromo-phore part. We found that PvsA, from Pseudomonas fluorescens ATCC 17400, and PvdL (PA2424), from Pseudomonas aeruginosa are similar NRPSs and functional homologues, necessary for the production of pyoverdine. Transcriptional lacZ fusions showed that pvdL is co-transcribed with the upstream PA2425 gene, encoding a putative thioesterase, and is iron-regulated via PvdS. Similarly, RT-PCR analysis revealed that expression of pvsA is repressed by iron. Analysis of the adenylation domains of PvsA, PvdL and their homologues, revealed that their N-terminus starts with an acyl-CoA ligase module, followed by three amino acid activation domains. Computer modelling of these domains suggests that PvsA in P. fluorescens and PvdL in P. aeruginosa are orthologues involved in the biosynthesis of the pyoverdine chromophore." @default.
- W1944333546 created "2016-06-24" @default.
- W1944333546 creator A5001021712 @default.
- W1944333546 creator A5004815237 @default.
- W1944333546 creator A5020990045 @default.
- W1944333546 creator A5024840687 @default.
- W1944333546 creator A5027199018 @default.
- W1944333546 creator A5032303230 @default.
- W1944333546 creator A5048740360 @default.
- W1944333546 creator A5053102600 @default.
- W1944333546 creator A5054756775 @default.
- W1944333546 creator A5061920110 @default.
- W1944333546 creator A5079179476 @default.
- W1944333546 date "2002-09-01" @default.
- W1944333546 modified "2023-10-18" @default.
- W1944333546 title "Identification of new, conserved, non-ribosomal peptide synthetases from fluorescent pseudomonads involved in the biosynthesis of the siderophore pyoverdine" @default.
- W1944333546 cites W1495926848 @default.
- W1944333546 cites W1522972296 @default.
- W1944333546 cites W1523578163 @default.
- W1944333546 cites W1945428462 @default.
- W1944333546 cites W1964516896 @default.
- W1944333546 cites W1968217232 @default.
- W1944333546 cites W1970386034 @default.
- W1944333546 cites W1974661505 @default.
- W1944333546 cites W1984116228 @default.
- W1944333546 cites W1984220817 @default.
- W1944333546 cites W1984939288 @default.
- W1944333546 cites W1986954897 @default.
- W1944333546 cites W1988521954 @default.
- W1944333546 cites W1993403449 @default.
- W1944333546 cites W1995122455 @default.
- W1944333546 cites W1997346743 @default.
- W1944333546 cites W1998109515 @default.
- W1944333546 cites W1998561479 @default.
- W1944333546 cites W2005091504 @default.
- W1944333546 cites W2012424005 @default.
- W1944333546 cites W2015642465 @default.
- W1944333546 cites W2017804401 @default.
- W1944333546 cites W2019367914 @default.
- W1944333546 cites W2020057555 @default.
- W1944333546 cites W2021540384 @default.
- W1944333546 cites W2024599746 @default.
- W1944333546 cites W2025921606 @default.
- W1944333546 cites W2026856098 @default.
- W1944333546 cites W2033767979 @default.
- W1944333546 cites W2035214478 @default.
- W1944333546 cites W2038087643 @default.
- W1944333546 cites W2044952215 @default.
- W1944333546 cites W2050499271 @default.
- W1944333546 cites W2052714501 @default.
- W1944333546 cites W2053998262 @default.
- W1944333546 cites W2057850803 @default.
- W1944333546 cites W2058681853 @default.
- W1944333546 cites W2064691604 @default.
- W1944333546 cites W2071486470 @default.
- W1944333546 cites W2075604429 @default.
- W1944333546 cites W2080895748 @default.
- W1944333546 cites W2083341941 @default.
- W1944333546 cites W2086532715 @default.
- W1944333546 cites W2086875378 @default.
- W1944333546 cites W2093468459 @default.
- W1944333546 cites W2105490489 @default.
- W1944333546 cites W2106154817 @default.
- W1944333546 cites W2111404134 @default.
- W1944333546 cites W2112077172 @default.
- W1944333546 cites W2114839447 @default.
- W1944333546 cites W2117482541 @default.
- W1944333546 cites W2132417094 @default.
- W1944333546 cites W2135255584 @default.
- W1944333546 cites W2136487582 @default.
- W1944333546 cites W2143372407 @default.
- W1944333546 cites W2144621559 @default.
- W1944333546 cites W2149224477 @default.
- W1944333546 cites W2151546112 @default.
- W1944333546 cites W2153390332 @default.
- W1944333546 cites W2157859065 @default.
- W1944333546 cites W2158714788 @default.
- W1944333546 cites W2161223276 @default.
- W1944333546 cites W2161425804 @default.
- W1944333546 cites W2165830458 @default.
- W1944333546 cites W2167170763 @default.
- W1944333546 cites W2168121531 @default.
- W1944333546 cites W2170788587 @default.
- W1944333546 cites W2172550932 @default.
- W1944333546 cites W2233117656 @default.
- W1944333546 cites W2236010489 @default.
- W1944333546 cites W2412269801 @default.
- W1944333546 cites W2462342881 @default.
- W1944333546 cites W2950506634 @default.
- W1944333546 cites W4244732422 @default.
- W1944333546 doi "https://doi.org/10.1046/j.1365-2958.2002.03120.x" @default.
- W1944333546 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12354233" @default.
- W1944333546 hasPublicationYear "2002" @default.
- W1944333546 type Work @default.
- W1944333546 sameAs 1944333546 @default.
- W1944333546 citedByCount "126" @default.
- W1944333546 countsByYear W19443335462012 @default.
- W1944333546 countsByYear W19443335462013 @default.