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• W1944666585 startingPage "5472" @default.
• W1944666585 abstract "The envelope glycoprotein of the human immunodeficiency virus type 2 (HIV-2) is synthesized as a polyprotein precursor which is proteolytically processed to produce the mature surface and transmembrane envelope glycoproteins. The processed envelope glycoprotein species are responsible for the fusion between the viral envelope and the host cell membrane during the infection process. The envelope glycoprotein also induces syncytium formation between envelope-expressing cells and receptor-bearing cells. To characterize domains of the HIV-2 envelope glycoprotein involved in membrane fusion and in proteolytic processing, we introduced single amino acid mutations into the region of the HIV-2 surface glycoprotein corresponding to the principal neutralizing determinant (the V3 loop) of HIV-1, the putative HIV-2 envelope precursor-processing sequence, and the hydrophobic amino terminus of the HIV-2 transmembrane envelope glycoprotein. The effects of these mutations on syncytium formation, virus infectivity, envelope expression, envelope processing, and CD4 binding were analyzed. Our results suggest that the V3-like region of the HIV-2 surface glycoprotein and the hydrophobic amino terminus of the transmembrane glycoprotein are HIV-2 fusion domains and characterize the effects of mutations in the HIV-2 envelope glycoprotein precursor-processing sequence." @default.
• W1944666585 created "2016-06-24" @default.
• W1944666585 creator A5034878155 @default.
• W1944666585 creator A5054660762 @default.
• W1944666585 date "1992-09-01" @default.
• W1944666585 modified "2023-09-25" @default.
• W1944666585 title "Identification and characterization of fusion and processing domains of the human immunodeficiency virus type 2 envelope glycoprotein" @default.
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• W1944666585 doi "https://doi.org/10.1128/jvi.66.9.5472-5478.1992" @default.
• W1944666585 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/289104" @default.
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• W1944666585 hasPublicationYear "1992" @default.
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