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- W1944689818 abstract "Immunosuppression by cyclophosphamide was used to make mice incapable of B-lymphocyte responses; they could not make an antibody response to NIP-Ficoll. These mice, as well as untreated mice, were challenged intraperitoneally with graded doses of isogenic O-4,12 or O-6,7 Salmonella typhimurium derivatives. The 50% lethal dose of the O-6,7 strains was 35- to 70-fold higher than that of the O-4,12 strains, both in the normal and the immunosuppressed animals, although the latter were approximately 1,000-fold more susceptible to the infection by either challenge organism. We conclude that the O-antigen-dependent difference in the mouse virulence of these sister strains is not mediated through differences in their capacity to evoke B-lymphocyte-mediated immune responses." @default.
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- W1944689818 date "1978-01-01" @default.
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- W1944689818 title "O antigen as virulence factor in mouse typhoid: effect of B-cell suppression" @default.
- W1944689818 doi "https://doi.org/10.1128/iai.19.1.26-28.1978" @default.
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