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• W1944892775 abstract "The Ca 2+ channel β subunit has been shown to reduce the magnitude of G-protein inhibition of Ca 2+ channels. However, neither the specificity of this action to different forms of G-protein inhibition nor the mechanism underlying this reduction in response is known. We have reported previously that coexpression of the Ca 2+ channel β 3 subunit causes M 2 muscarinic receptor-mediated inhibition of α 1B Ca 2+ currents to become more voltage-dependent. We report here that the β 3 subunit increases the rate of relief of inhibition produced by a depolarizing prepulse and also shifts the voltage dependency of this relief to more hyperpolarized voltages; these effects are likely to be responsible for the reduction of inhibitory response of α 1B channels to G-protein-mediated inhibition seen after coexpression of the Ca 2+ channel β 3 subunit. Additionally, the β 3 subunit alters the rate and voltage dependency of relief of the inhibition produced by coexpressed G β1γ1 , in a manner similar to the changes it produces in relief of M 2 receptor-induced inhibition. We conclude that the Ca 2+ channel β 3 subunit reduces the magnitude of G-protein inhibition of α 1B Ca 2+ channels by enhancing the rate of dissociation of the G-protein βγ subunit from the Ca 2+ channel α 1B subunit." @default.
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• W1944892775 creator A5067734027 @default.
• W1944892775 date "1998-07-01" @default.
• W1944892775 modified "2023-10-18" @default.
• W1944892775 title "Ca²⁺Channel β₃Subunit Enhances Voltage-Dependent Relief of G-Protein Inhibition Induced by Muscarinic Receptor Activation and G_βγ" @default.
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• W1944892775 doi "https://doi.org/10.1523/jneurosci.18-13-04883.1998" @default.
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