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- W1945013172 abstract "Oneofthemostchallengingclinicalsituationsinpatientswithdifferentiated thyroid cancer (DTC) is an elevated serum thy-roglobulin (Tg) level with negative radioiodine scintigraphy(commonlytermedBTENIS^).Thediagnosticandtherapeuticapproaches adopted by attending physicians in day-to-dayroutine vary quite widely. The main reason for this variationis the rarity of the condition (2 – 13 % from various seriesreported in literature), and its management, especially thera-peuticstrategies, continues tobeimperfect intheabsenceofaclear-cut understanding and lack of evidence of its aetiology,as observed by various authorities [1]. In this editorial, wediscuss the different therapeutic strategies that have beenexplored and the associated pitfalls in interpretation ofclinical findings, and propose a logical step-wise algo-rithmic approach to care to follow in routine clinics inthis particular group of patients. Our views are support-ed by an overview of the evidence in the literature(with respect to both efficacy and adverse effects) andby practical experience. In addition, we critically reviewand analyse the steps needed in the immediate future toenhance and rationalize patient care. We believe thatsuch endeavours toidentifyandprioritizethechallengeswillfurther the roadmap to the development of a systematicand scientific approach to themanagementofpatientswithTENIS." @default.
- W1945013172 created "2016-06-24" @default.
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- W1945013172 date "2015-05-20" @default.
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- W1945013172 title "Defining a rational step-care algorithm for managing thyroid carcinoma patients with elevated thyroglobulin and negative on radioiodine scintigraphy (TENIS): considerations and challenges towards developing an appropriate roadmap" @default.
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- W1945013172 doi "https://doi.org/10.1007/s00259-015-3058-x" @default.
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