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• W1945249196 abstract "Angiotensin II (AII) as well as analog peptides shows antimalarial activity against Plasmodium gallinaceum and Plasmodium falciparum, but the exact mechanism of action is still unknown. This work presents the solid-phase synthesis and characterization of eight peptides corresponding to the alanine scanning series of AII plus the amide-capped derivative and the evaluation of the antiplasmodial activity of these peptides against mature P. gallinaceum sporozoites. The Ala screening data indicates that the replacement of either the Ile(5) or the His(6) residues causes minor effects on the in vitro antiplasmodial activity compared with AII, i.e. AII (88%), [Ala(6) ]-AII (79%), and [Ala(5) ]-AII (75%). Analogs [Ala(3) ]-AII, [Ala(1) ]-AII, and AII-NH2 showed antiplasmodial activity around 65%, whereas the activity of the [Ala(8) ]-AII, [Ala(7) ]-AII, [Ala(4) ]-AII, and [Ala(2) ]-AII analogs is lower than 45%. Circular dichroism data suggest that AII and the most active analogs adopt a β-fold conformation in different solutions. All AII analogs, except [Ala(4) ]-AII and [Ala(8) ]-AII, show contractile responses and interact with the AT1 receptor, [Ala(5) ]-AII and [Ala(6) ]-AII. In conclusion, this approach is helpful to understand the contribution of each amino acid residue to the bioactivity of AII, opening new perspectives toward the design of new sporozoiticidal compounds." @default.
• W1945249196 created "2016-06-24" @default.
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• W1945249196 date "2014-05-09" @default.
• W1945249196 modified "2023-10-05" @default.
• W1945249196 title "Antiplasmodial activity study of angiotensin II via Ala scan analogs" @default.
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• W1945249196 cites W1573986638 @default.
• W1945249196 cites W1583655086 @default.
• W1945249196 cites W1777056623 @default.
• W1945249196 cites W1814485686 @default.
• W1945249196 cites W1849892318 @default.
• W1945249196 cites W1970355219 @default.
• W1945249196 cites W1971592544 @default.
• W1945249196 cites W1972208799 @default.
• W1945249196 cites W1975304761 @default.
• W1945249196 cites W1977776474 @default.
• W1945249196 cites W1978476654 @default.
• W1945249196 cites W1978998472 @default.
• W1945249196 cites W1985926451 @default.
• W1945249196 cites W1989075474 @default.
• W1945249196 cites W1989451255 @default.
• W1945249196 cites W1990332976 @default.
• W1945249196 cites W1990351031 @default.
• W1945249196 cites W1990656555 @default.
• W1945249196 cites W1991369368 @default.
• W1945249196 cites W2000293651 @default.
• W1945249196 cites W2002274759 @default.
• W1945249196 cites W2003804603 @default.
• W1945249196 cites W2004350450 @default.
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• W1945249196 cites W2020755269 @default.
• W1945249196 cites W2023913233 @default.
• W1945249196 cites W2025842576 @default.
• W1945249196 cites W2026485221 @default.
• W1945249196 cites W2031224292 @default.
• W1945249196 cites W2037455416 @default.
• W1945249196 cites W2039429855 @default.
• W1945249196 cites W2044456123 @default.
• W1945249196 cites W2046704370 @default.
• W1945249196 cites W2049275627 @default.
• W1945249196 cites W2056101692 @default.
• W1945249196 cites W2059993313 @default.
• W1945249196 cites W2064838148 @default.
• W1945249196 cites W2066804606 @default.
• W1945249196 cites W2076721712 @default.
• W1945249196 cites W2085200874 @default.
• W1945249196 cites W2085304825 @default.
• W1945249196 cites W2093678823 @default.
• W1945249196 cites W2097021608 @default.
• W1945249196 cites W2101792514 @default.
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• W1945249196 cites W2119730466 @default.
• W1945249196 cites W2127236008 @default.
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• W1945249196 cites W2153057337 @default.
• W1945249196 cites W2156069524 @default.
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• W1945249196 cites W2168950392 @default.
• W1945249196 cites W2170017808 @default.
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• W1945249196 cites W2320556745 @default.
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• W1945249196 doi "https://doi.org/10.1002/psc.2641" @default.
• W1945249196 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24817179" @default.
• W1945249196 hasPublicationYear "2014" @default.
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